Home > Name List By 1 > 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4, 6-triiodobenzene-1,3-dicarboxamide

CAS No 78649-41-9 , 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,
6-triiodobenzene-1,3-dicarboxamide

  • Name: 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,
    6-triiodobenzene-1,3-dicarboxamide
  • Synonyms: Iomeprolum [INN-Latin]; NCGC00183283-01;Iomeprolum;1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,
    6-triiodobenzene-1,3-dicarboxamide; CHEBI:31710; 78649-41-9; Iomeprolo;
  • CAS Registry Number:
  • Flash Point: 445.6°C
  • Boiling Point: 813.2°C at 760 mmHg
  • Density: 2.27g/cm3
  • Refractive index: 1.734
  • Safety Statements: Low toxicity by intravenous and intracerebral routes. When heated to decomposition it emits toxic vapors of NOx and I−.
  • Hazard Symbols: Low toxicity.
  • Flash Point: 445.6°C
  • Molecular Weight: 777.08529
  • InchiKey: NJKDOADNQSYQEV-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H22I3N3O8/c1-23(9(29)6-26)15-13(19)10(16(30)21-2-7(27)4-24)
    12(18)11(14(15)20)17(31)22-3-8(28)5-25/h7-8,24-28H,2-6H2,1H3,(H,21,
    30)(H,22,31)
  • Molecular Formula: C17H22I3N3O8
  • Molecular Structure:CAS No:78649-41-9 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,<br />6-triiodobenzene-1,3-dicarboxamide

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78649-41-9 Iomeprol

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78649-41-9 1,3-Benzenedicarboxamide,N1,N3-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)methylamino]-2,4,6-triiodo-

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78649-41-9 IOMEPROL

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References of 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[(2-hydroxyacetyl)-methylamino]-2,4,
6-triiodobenzene-1,3-dicarboxamide
Title: Iomeprol
CAS Registry Number: 78649-41-9
CAS Name: N,N￠-Bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide
Synonyms: N,N￠-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(N-methylglycolamido)isophthalamide
Manufacturers' Codes: B-16880
Trademarks: Imeron (Bracco); Iomeron (Bracco)
Molecular Formula: C17H22I3N3O8
Molecular Weight: 777.09
Percent Composition: C 26.28%, H 2.85%, I 48.99%, N 5.41%, O 16.47%
Literature References: Nonionic x-ray contrast media. Prepn: E. Felder, D. Pitrè, EP 026281; eidem, US 4352788 (1981, 1982 both to Bracco). HPLC determn in plasma and urine: V. Lorusso et al., J. Chromatogr. 525, 401 (1990). Series of articles on properties, pharmacology, pharmacokinetics and clinical experience in angiography and urography: Eur. J. Radiol. 18, Suppl. 1, S1-S124 (1994). Toxicology study: A. Morisetti et al., ibid. S21.
Properties: Crystalline powder, mp 285-291° (dec). Extremely sol in water, very sol in methanol, poorly sol in ethanol. Practically insol in chloroform. Aqueous soln of 150 mg I/ml: d420 1.166, d437 1.161; osmolality (37°) 0.27 osmol/kg H2O; viscosity at 20° (mPa.s) 1.9, at 37° 1.3; nD20 1.3828. Aqueous soln of 300 mg I/ml: d420 1.334, d437 1.329; osmolality (37°) 0.52 osmol/kg H2O; viscosity at 20° (mPa.s) 8.4, at 37° 4.8; nD20 1.4327. Aqueous soln of 400 mg I/ml: d420 1.446, d437 1.441; osmolality (37°) 0.72 osmol/kg H2O; viscosity at 20° (mPa.s) 28.9, at 37° 13.9; nD20 1.4660. LD50 (400 mgI/ml soln) i.v. in mice, rats (gI/kg): 19.9, 14.5; LD50 (370 mgI/ml soln) i.v. in dogs (gI/kg): >12.5 (Morisetti).
Melting point: mp 285-291° (dec)
Index of refraction: nD20 1.3828; nD20 1.4327; nD20 1.4660
Density: d420 1.166; d437 1.161; d420 1.334; d437 1.329; d420 1.446; d437 1.441
Toxicity data: LD50 (400 mgI/ml soln) i.v. in mice, rats (gI/kg): 19.9, 14.5; LD50 (370 mgI/ml soln) i.v. in dogs (gI/kg): >12.5 (Morisetti)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).