Home > Name List By other > (2R,6S)-2, 6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine

CAS No 78613-35-1 , (2R,6S)-2,
6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine

  • Name: (2R,6S)-2,
    6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
  • Synonyms: Amorolfinum;(2R,6S)-2,
    6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine;amorolfin; 78613-35-1; NCGC00167524-01; 67467-83-8; Amorolfina; CHEBI:599440; Loceryl; Ro 14-4767-002;
  • CAS Registry Number:
  • Melting Point: 134
  • Density: 0.924 g/cm3
  • Safety Statements: S26;S36;
  • Hazard Symbols: Xn
  • Molecular Weight: 317.5087
  • InchiKey: MQHLMHIZUIDKOO-AYHJJNSGSA-N
  • InChI: InChI=1S/C21H35NO/c1-7-21(5,
    6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,
    12-15H2,1-6H3/t16?,17-,18+
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C21H35NO
  • Molecular Structure:CAS No:78613-35-1 (2R,6S)-2,<br />6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine

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78613-35-1 Morpholine,4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-rel-

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References of (2R,6S)-2,
6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
Title: Amorolfine
CAS Registry Number: 78613-35-1
CAS Name: cis-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine
Synonyms: cis-4-[3-(4-tert-amylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine; (±)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine
Manufacturers' Codes: Ro-14-4767/000
Molecular Formula: C21H35NO
Molecular Weight: 317.51
Percent Composition: C 79.44%, H 11.11%, N 4.41%, O 5.04%
Literature References: Antimycotic morpholine derivative; inhibits fungal ergosterol biosynthesis. Prepn (unspec stereochem): A. Pfiffner, K. Bohnen, DE 2752096; A. Pfiffner, US 4202894 (1978, 1980 both to Hoffmann-La Roche); of cis-form: NL 8004537 (1980 to Hoffmann-La Roche). In vitro comparative antifungal spectrum: S. Shadomy et al., Sabouraudia 22, 7 (1984). Mechanism of action: A. Polak-Wyss et al., ibid. 23, 433 (1985); A. Polak, Ann. N.Y. Acad. Sci. 544, 221 (1988). LC determn in pharmaceutical formulations: M. A. Czech et al., J. Pharm. Biomed. Anal. 9, 1019 (1991). Series of articles on mode of action and clinical trials: Clin. Exp. Dermatol. 17, Suppl. 1, 1-70 (1992). Review of pharmacology and clinical efficacy: M. Haria, H. M. Bryson, Drugs 49, 103-120 (1995).
Properties: bp0.1 120°.
Boiling point: bp0.1 120°
 
Derivative Type: Hydrochloride
CAS Registry Number: 78613-38-4
Manufacturers' Codes: Ro-14-4767/002
Trademarks: Loceryl (Roche)
Molecular Formula: C21H35NO.HCl
Molecular Weight: 353.97
Percent Composition: C 71.26%, H 10.25%, N 3.96%, O 4.52%, Cl 10.02%
 
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic).