CAS No 78415-72-2 , 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile Search by region : Germany

Name: 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Synonyms: Corotrop; Milrinonum; Milrila;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile; Milrinona [Spanish]; Milrinonum [Latin]; Milrinona; Corotrope; 78415-72-2;Primacor;
CAS Registry Number:78415-72-2
Transport: UN 2811
Melting Point: >3000C
Density: 1.28 g/cm³
Water Solubility: DMSO: >10 mg/mL
Safety Statements: R23/24/25
Hazard Symbols: T: Toxic;
EINECS: 278-903-6
Molecular Weight: 211.21936
InchiKey: PZRHRDRVRGEVNW-UHFFFAOYSA-N
InChI: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,
(H,15,16)
Risk Statements: S36/37/39;S45
Molecular Formula: C₁₂H₉N₃O
Molecular Structure:

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           78415-72-2 MILRINONE
           
             CHEMOS GmbH
             
              [Manufacturer]
Tel:  0049 9402/9336 0
Fax:  0049 9402/9336 13
Address: CHEMOS GmbH 
Werner-von-Siemensstr. 3 
93128 Regenstauf 
Germany null,nullGermany

           78415-72-2 MILRINONE
           
             BIOTREND Chemikalien GmbH
             
              [Manufacturer]
Tel:  ++49 (0)2 21 9 49 83 20
Fax:  ++49 (0)2 21 9 49 83 25
Address: BIOTREND Chemikalien GmbH 
Eupener Str. 157 
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Germany null,nullGermany

           78415-72-2 MILRINONE
           
             CEDA Chemicals GmbH
             
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Tel:  + 49 - 25 94 - 78 31 40 - 0
Fax:  + 49 - 25 94 - 78 31 40 - 22
Address: CEDA Chemicals GmbH
Fehrbelliner Platz 1
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Germany null,nullGermany

           78415-72-2 MILRINONE
           
             Boehringer Ingelheim GmbH
             
              [Manufacturer]
Tel:  ++49 6132 77 2192
Fax:  ++49 6132 77 4227
Address: C Dept.
Pharma Chemicals
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D-55216 Ingelheim / Germany null,nullGermany

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References of 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile

Title: Milrinone
CAS Registry Number: 78415-72-2
CAS Name: 1,6-Dihydro-2-methyl-6-oxo-(3,4￠-bipyridine)-5-carbonitrile
Synonyms: 1,2-dihydro-6-methyl-2-oxo-5-(4-pyridinyl)nicotinonitrile
Manufacturers' Codes: Win-47203
Trademarks: Corotrope (Sanofi-Synthelabo); Milrila (Yamanouchi)
Molecular Formula: C12H9N3O
Molecular Weight: 211.22
Percent Composition: C 68.24%, H 4.29%, N 19.89%, O 7.57%
Literature References: Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Prepn: G. Y. Lesher et al., BE 886336; G. Y. Lesher, R. E. Philion, US 4313951 (1981, 1982 both to Sterling). Improved process: B. Singh, US 4413127 (1983 to Sterling); idem, Heterocycles 23, 1479 (1985). Pharmacological profile: A. A. Alousi et al., J. Cardiovasc. Pharmacol. 5, 792, 804 (1983). HPLC determn in body fluids: J. Edelson et al., J. Chromatogr. 276, 456 (1983). Clinical studies in congestive heart failure: C. S. Maskin et al., Circulation 67, 1065 (1983); L. S. Sinoway et al., J. Am. Coll. Cardiol. 2, 327 (1983); D. S. Baim et al., N. Engl. J. Med. 309, 748 (1983).
Properties: Crystals from DMF + water or from ethanol, mp >300°.
Melting point: mp >300°

Derivative Type: Lactate
CAS Registry Number: 100286-97-3
Trademarks: Primacor (Sanofi-Synthelabo)
Line Formula: C12H9N3O.xC3H6O3

Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.