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CAS No 78281-72-8 , 2-(2-amino-3-benzoylphenyl)acetamide

  • Name: 2-(2-amino-3-benzoylphenyl)acetamide
  • Synonyms: AHR-9434; 78281-72-8;Nevanac; AL 6515; 2-(2-Amino-3-benzoylphenyl)acetamide; 2-Amino-3-benzoylbenzeneacetamide; AL-6515; Amfenac amide;2-(2-amino-3-benzoylphenyl)acetamide;
  • CAS Registry Number:
  • Density: 1.249 g/cm3
  • Refractive index: 1.641
  • Molecular Weight: 254.28386
  • InchiKey: QEFAQIPZVLVERP-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-
    10/h1-8H,9,17H2,(H2,16,18)
  • Molecular Formula: C15H14N2O2
  • Molecular Structure:CAS No:78281-72-8 2-(2-amino-3-benzoylphenyl)acetamide

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References of 2-(2-amino-3-benzoylphenyl)acetamide
Title: Nepafenac
CAS Registry Number: 78281-72-8
CAS Name: 2-Amino-3-benzoylbenzeneacetamide
Manufacturers' Codes: AHR-9434; AL-6515
Trademarks: Nevanac (Alcon)
Molecular Formula: C15H14N2O2
Molecular Weight: 254.28
Percent Composition: C 70.85%, H 5.55%, N 11.02%, O 12.58%
Literature References: Nonsteroidal anti-inflammatory with analgesic activity; selective COX-2 inhibitor. Prodrug of amfenac, q.v. Prepn: D. A. Walsh et al., DE 3035688 (1981 to A. H. Robins); see also: J. R. Shanklin, Jr. et al., US 4313949 (1982 to A. H. Robins); D. A. Walsh et al., J. Med. Chem. 33, 2296 (1990). Ocular pharmacology: D. A. Gamache et al., Inflammation 24, 357 (2000); T.-L. Ke et al., ibid. 371. Inhibition of ocular neovascularization: K. Takahashi et al., Invest. Ophthalmol. Visual Sci. 44, 409 (2003). Review of clinical experience: R. Lindstrom, T. Kim, Curr. Med. Res. Opin. 22, 397-404 (2006).
Properties: Yellow needles from isopropyl alcohol, mp 178.5-180.0°.
Melting point: mp 178.5-180.0°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.