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CAS No 77-86-1 , 2-amino-2-(hydroxymethyl)propane-1,3-diol Search by region : China

  • Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
  • Synonyms: Tris buffer; Tris(Hydroxymethyl)aminomethane; Trisamine; Tromethane;2-amino-2-(hydroxymethyl)propane-1,3-diol; Trizma;Trometamol; Tris; Tham; 77-86-1;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 167-172 ºC
  • Boiling Point: 219-220 ºC (10 MMHG)
  • Density: 1,353 g/cm3
  • Refractive index: 1.531
  • Water Solubility: 550 G/L (25 ºC)
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • HS Code: 29221980
  • EINECS: 201-064-4
  • Molecular Weight: 121.13504
  • InchiKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
  • Risk Statements: S26;S37/39
  • Molecular Formula: C4H11NO3
  • Molecular Structure:CAS No:77-86-1 2-amino-2-(hydroxymethyl)propane-1,3-diol

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77-86-1 Tris(hydroxymethyl)aminomethane

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  • is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology.[1] In biochemistry, Tris is widely used as a component of buffer solutions, such as in TAE and TBE buffer, especially for solutions of...
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    • 77-86-1 TRIS

    • "Appearance White crystal Assay 99.50%-101.0% Melting point 168°C-171°C Insolubles 0.03% max ASH 0.05% max Heavy metals 5ppm max Loss on drying 0.2% max PH 10.0-10.8 Color 5# Fe 1ppm max SO42+ 10ppm max Cl 3ppm max Abs (260nm,20%water) 0.1 max"
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    77-86-1 Tris(hydroxymethyl)aminoethane

    • Name:Tris(hydroxymethyl)aminoethane CAS:77-86-1 Synonyms:Tris MF:C4H11NO3 MW:121.14 Purity:≥99% Density:1.353 g/cm3 Melting Point:167-172 °C(lit.) Boiling Point:219-220 °C10 mm Hg(lit.) Flash Point:219-220°C/10mm Appearance:White crystalline or powd...
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    References of 2-amino-2-(hydroxymethyl)propane-1,3-diol
    Title: Tromethamine
    CAS Registry Number: 77-86-1
    CAS Name: 2-Amino-2-hydroxymethyl-1,3-propanediol
    Synonyms: trimethylol aminomethane; tris(hydroxymethyl)aminomethane; trisamine; tris buffer; trometamol; tromethane; TRIS
    Trademarks: THAM (Fisher Sci.); Trizma (Sigma-Aldrich)
    Molecular Formula: C4H11NO3
    Molecular Weight: 121.14
    Percent Composition: C 39.66%, H 9.15%, N 11.56%, O 39.62%
    Literature References: May be prepd by reduction or catalytic hydrogenation of the corresp nitro compd. Prepn of similar compds: Hass, Vanderbilt, US 2174242 (1940); Johnson, Degering, J. Org. Chem. 8, 7 (1943); Boileau, Mem. Poudres 35, Annexe 7-76 (1953). Prepn by electrolytic reduction: McMillan, US 2485982 (1949 to Comm. Solvents Corp.). Titrimetric standard: Whitehead, J. Chem. Educ. 36, 297 (1959). Monograph: Ann. N.Y. Acad. Sci. 92, Art. 2, pp 333-812 (June 17, 1961). Crystal structure: R. Rudman et al., Science 200, 531 (1978). GC determn in plasma: H. Hulshoff, H. B. Kostenbauder, J. Chromatogr. 145, 155 (1978). Pharmacokinetics in rabbits: H. Brasch, H. Iven, Arch. Int. Pharmacodyn. 254, 4 (1981). Use as a biological buffer: R. A. Durst, B. R. Staples, Clin. Chem. 18 206 (1972); S. P. Fling, D. S. Gregerson, Anal. Biochem. 155, 83 (1986); T. Higa, D. M. Desiderio, ibid. 173, 463 (1988). Interaction with hydroxyl radicals: M. Hicks, J. M. Gebicki, FEBS Lett. 199, 92 (1986). Review of clinical experience in treatment of acidemia: G. G. Nahas et al., Drugs 55, 191-224 (1998).
    Properties: Crystalline mass, mp 171-172°. bp10 219-220°. Weak, monoacidic base: pKb (25°): 5.91. pKa (20°): 8.3. pKa (37°): 7.82. pH of 0.1 molar aq soln 10.4. Aq solns do not absorb CO2 from the air. Soly at 25° (mg/ml) in water: 550; ethylene glycol: 79.1; methanol: 26; anhydr ethanol: 14.6; 95% ethanol: 22.0; DMF: 14; acetone: 2.0; ethyl acetate: 0.5; olive oil: 0.4; cyclohexane: 0.1; chloroform: 0.05; carbon tetrachloride: <0.05.
    Melting point: mp 171-172°
    Boiling point: bp10 219-220°
    pKa: pKb (25°): 5.91; pKa (20°): 8.3; pKa (37°): 7.82
    Use: In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
    Therap-Cat: Alkalinizing agent.
    Keywords: Alkalinizing Agent.