Home > Name List By 3 > 3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1, 4-benzodiazepin-1-yl]propanenitrile

CAS No 75696-02-5 , 3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,
4-benzodiazepin-1-yl]propanenitrile

  • Name: 3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,
    4-benzodiazepin-1-yl]propanenitrile
  • Synonyms: CHEBI:59514; Cinolazepamum [INN-Latin]; AC1Q7ARL;Gerodorm; Gerodorm (TN); Cinolazepam (INN); Cinolazepamum; Cinolazepam [INN];3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,
    4-benzodiazepin-1-yl]propanenitrile; OX-373;
  • CAS Registry Number:
  • Flash Point: 343°C
  • Boiling Point: 643.5°C at 760 mmHg
  • Density: 1.39g/cm3
  • Refractive index: 1.646
  • Flash Point: 343°C
  • Molecular Weight: 357.766123
  • InchiKey: XAXMYHMKTCNRRZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-
    17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2
  • Molecular Formula: C18H13ClFN3O2
  • Molecular Structure:CAS No:75696-02-5 3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,<br />4-benzodiazepin-1-yl]propanenitrile

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References of 3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,
4-benzodiazepin-1-yl]propanenitrile
Title: Cinolazepam
CAS Registry Number: 75696-02-5
CAS Name: 7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-3-hydroxy-2-oxo-1H-1,4-benzodiazepine-1-propanenitrile
Synonyms: 1-(2-cyanoethyl)-7-chloro-3-hydroxy-5-(2￠-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Manufacturers' Codes: OX-373
Trademarks: Gerodorm (Gerot)
Molecular Formula: C18H13ClFN3O2
Molecular Weight: 357.77
Percent Composition: C 60.43%, H 3.66%, Cl 9.91%, F 5.31%, N 11.75%, O 8.94%
Literature References: Prepn: L. H. Schlager, DE 2950235; idem, US 4388313 (1980, 1983 both to Gerot). Benzodiazepine receptor affinity: W. Sieghart, A. Schuster, Biochem. Pharmacol. 33, 4033 (1984). Polarographic and HPLC analyses: H. Oelschl?ger et al., Arch. Pharm. 325, 65 (1992). Clinical pharmacokinetics: J. Grünberger et al., Adv. Ther. 4, 84 (1987). Clinical evaluation in insomnia: B. Saletu et al., Int. J. Clin. Pharmacol. Res. 7, 407 (1987).
Properties: Crystals from ethanol, mp 190-193°.
Melting point: mp 190-193°
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Benzodiazepine Derivatives.