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CAS No 7554-65-6 , 4-methyl-1H-pyrazole

  • Name: 4-methyl-1H-pyrazole
  • Synonyms: Fomepizol; 7554-65-6; fomepizole;4-Methylpyrazole; Antizol; 1H-Pyrazole; 4-Methylpyrazol; 4-Methyl-1H-pyrazole;4-methyl-1H-pyrazole; Fomepizol [INN-Spanish]; 4-methyl-;
  • CAS Registry Number:
  • Transport: 2810
  • Melting Point: 13°C
  • Flash Point: 96 ºC
  • Boiling Point: 99-100 ºC (6 MMHG)
  • Density: 0.993
  • Refractive index: 1.493-1.495
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 96 ºC
  • EINECS: 231-445-0
  • Molecular Weight: 82.10384
  • InchiKey: RIKMMFOAQPJVMX-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
  • Risk Statements: S24/25
  • Molecular Formula: C4H6N2
  • Molecular Structure:CAS No:7554-65-6 4-methyl-1H-pyrazole

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References of 4-methyl-1H-pyrazole
Title: Fomepizole
CAS Registry Number: 7554-65-6
CAS Name: 4-Methyl-1H-pyrazole
Synonyms: 4-MP
Trademarks: Antizol (Orphan Med.)
Molecular Formula: C4H6N2
Molecular Weight: 82.10
Percent Composition: C 58.52%, H 7.37%, N 34.12%
Literature References: Alcohol dehydrogenase inhibitor. Prepn: H. Pechmann, E. Burkard, Ber. 33, 3590 (1900); D. S. Noyce et al., J. Org. Chem. 20, 1681 (1955); T. Momose et al., Heterocycles 30, 789 (1990). Inhibition of human liver alcohol dehydrogenase: T.-K. Li, H. Theorell, Acta Chem. Scand. 23, 892 (1969). Toxicity study: G. Magnusson et al., Experientia 28, 1198 (1972). GC determn in plasma and urine: R. Achari, M. Mayersohn, J. Pharm. Sci. 73, 690 (1984). Clinical pharmacology: D. Jacobsen et al., Alcohol. Clin. Exp. Res. 12, 516 (1988). Pharmacokinetics: eidem, Eur. J. Clin. Pharmacol. 37, 599 (1989). Clinical trial in ethylene glycol poisoning: J. Brent et al., N. Engl. J. Med. 340, 832 (1999); in methanol poisoning: idem et al., ibid. 344, 424 (2001). Review: J. Likforman et al., J. Toxicol. Clin. Exp. 7, 373-382 (1987). Review of use in methanol poisoning: M. B. Mycyk, J. B. Leikin, Am. J. Therapeut. 10, 68-70 (2003).
Properties: mp 15.5-18.5°. bp18mm 98.5-99.5°; bp730 204-205°. nD22 1.4913. uv max in 95% ethanol: 220 nm (log e 3.47); in 6N HCl: 226 nm (log e 3.65). Sol in water, alcohol. LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson).
Melting point: mp 15.5-18.5°
Boiling point: bp18mm 98.5-99.5°; bp730 204-205°
Index of refraction: nD22 1.4913
Absorption maximum: uv max in 95% ethanol: 220 nm (log e 3.47); in 6N HCl: 226 nm (log e 3.65)
Toxicity data: LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)
Therap-Cat: Antidote to methanol and ethylene glycol poisoning.
Therap-Cat-Vet: Antidote to ethylene glycol poisoning in dogs.
Keywords: Antidote (Methanol and Ethylene Glycol Poisoning).