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CAS No 7542-37-2 , Paromomycin

  • Name: Paromomycin
  • Synonyms: Gabromycin;3)-O-b-D-ribofuranosyl-(1® Hydroxymycin (6CI);5)]-2-deoxy-;4)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1® Quintomycin C;Antibiotic SF 767B;Paromomycin; Humycin;5)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(1® Crestomycin;Aminosidine; Monomycin A; Amminosidin; Zygomycin A1 (7CI);D-Streptamine,O-2-amino-2-deoxy-a-D-glucopyranosyl-(1® Antibiotic 2230D; Aminosidine I; Antibiotic 503-3; Paucimycin;3)-b-D-ribofuranosyl-(1® Aminosidin; Paromomycin; Neomycin E; Paromomycin I; Catenulin;Paromomycine; Gabbromicina; Gabbromycin;4)]-2-deoxy- (8CI); R 400; Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1®
  • CAS Registry Number:
  • Flash Point: 522.2°C
  • Boiling Point: 939.8°C at 760 mmHg
  • Density: 1.64g/cm3
  • Refractive index: 1.676
  • Safety Statements: Moderately toxic by ingestion, intramuscular, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 522.2°C
  • EINECS: 231-423-0
  • Molecular Weight: 615.63
  • InChI: InChI=1/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?/m1/s1
  • Molecular Formula: C23H45N5O14
  • Molecular Structure:CAS No:7542-37-2 Paromomycin

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7542-37-2 Paromomycin

  • Aminoglycoside Antibiotic CAS NO.7542-37-2 Paromomycin for treatment of Intestines Parasite Infection Quick Datails: Product Name: Paromomycin CAS Registry NO.: 7542-37-2 Molecular Formula : C23H45N5O14 Molecular Weight: 615.63 EINECS NO.: 231-423-0 ...
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References of Paromomycin
Title: Paromomycin
CAS Registry Number: 7542-37-2
CAS Name: O-2-Amino-2-deoxy-a-D-glucopyranosyl-(1?4)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1?3)-b-D-ribofuranosyl-(1?5)]-2-deoxy-D-streptamine
Synonyms: O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(1?3)-O-b-D-ribofuranosyl-(1?5)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(1?4)]-2-deoxystreptamine; paromomycin I; amminosidin; catenulin; crestomycin; estomycin; hydroxymycin; monomycin A; neomycin E; paucimycin
Manufacturers' Codes: R-400
Molecular Formula: C23H45N5O14
Molecular Weight: 615.63
Percent Composition: C 44.87%, H 7.37%, N 11.38%, O 36.38%
Literature References: Oligosaccharide-type antibiotic isolated from various Streptomyces. From S. rimosus forma paromomycinus: Frohardt et al., US 2916485 (1959 to Parke, Davis); from S. catenulae: Davisson, Finlay, US 2895876 (1959 to Pfizer); from S. chrestomyceticus: Canevazzi, Scotti, G. Microbiol. 7, 242 (1959); Arcamone et al., ibid. 251. Identity of paromomycin, catenulin, hydroxymycin and aminosidine: Schillings, Schaffner, Antimicrob. Agents Chemother. 1961, 274. Structure: Haskell et al., J. Am. Chem. Soc. 81, 3480, 3482 (1959); Rinehart et al., ibid. 84, 3218 (1962); Hichens, Rinehart, ibid. 85, 1547 (1963). Probable identity with zygomycin A: Horii, J. Antibiot. 15A, 187 (1962). Identity with monomycin A: Konstantinova, Brazhnikova, Antibiotiki 10(1), 34 (1965); with neomycin E: Hessler et al., J. Antibiot. 23, 464 (1970). Toxicity data: A. DiMarco, C. Bertazzoli, Antibiot. Chemother. 11, 2 (1963). Review of antimicrobial activity: G. L. Coffey et al., ibid. 9, 730 (1959). Review of pharmacology: Gasparini, Pignatelli, Veterinaria (Milan) 21, 7 (1972).
Properties: Amorphous white powder. [a]D25 +65 ±3°. Soluble in water; moderately sol in methanol; sparingly sol in abs ethanol. LD50 in rats, mice (mg/kg): >1625, >2275 orally; >650, 423 s.c.; 156, 90 i.v. (Coffey).
Optical Rotation: [a]D25 +65 ±3°
Toxicity data: LD50 in rats, mice (mg/kg): >1625, >2275 orally; >650, 423 s.c.; 156, 90 i.v. (Coffey)
 
Derivative Type: Sulfate
CAS Registry Number: 1263-89-4
Manufacturers' Codes: 1600 Antibiotic; FI-5853
Trademarks: Aminoxidin (Farmitalia); Aminosidine (Kyowa); Farmiglucin (Farmitalia); Farminosidin (Farmitalia); Gabbromicina (Farmitalia); Gabbromycin (Farmitalia); Gabbroral (Farmitalia); Humagel (Parke-Davis); Humatin (Parke-Davis); Pargonyl; Paramicina (Raglionieri); Paricina (Archifar); Sinosid (SIF)
Molecular Formula: C23H45N5O14.H2SO4
Molecular Weight: 713.71
Percent Composition: C 38.71%, H 6.64%, N 9.81%, O 40.35%, S 4.49%
Properties: [a]D25 +50.5° (c = 1.5 in water pH 6). LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli).
Optical Rotation: [a]D25 +50.5° (c = 1.5 in water pH 6)
Toxicity data: LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)
 
Therap-Cat: Antibacterial; antiamebic.
Therap-Cat-Vet: Antiamebic.
Keywords: Antiamebic; Antibacterial (Antibiotics); Aminoglycosides.