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CAS No 75272-39-8 , Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-,rel-

  • Name: Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-,rel-
  • Synonyms: Emilace; Nemonapride;Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-,rel-; YM 09151; YM 09151-2;Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-,cis-; Emonapride;
  • CAS Registry Number:
  • Flash Point: 265.2°C
  • Boiling Point: 514.9°C at 760 mmHg
  • Density: 1.23g/cm 3
  • Flash Point: 265.2°C
  • Molecular Weight: 387.9
  • InChI: InChI=1S/C21H26ClN3O2/c1-14-18(9-10-25(14)13-15-7-5-4-6-8-15)24-21(26)16-11-17(22)19(23-2)12-20(16)27-3/h4-8,11-12,14,18,23H,9-10,13H2,1-3H3,(H,24,26)/t14-,18-/m1/s1
  • Molecular Formula: C21H26ClN3O2
  • Molecular Structure:CAS No:75272-39-8 Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-,rel-

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75272-39-8 Nemonapride

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References of Benzamide,5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-,rel-
Title: Nemonapride
CAS Registry Number: 75272-39-8
CAS Name: rel-5-Chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-2-(phenylmethyl)-3-pyrrolidinyl]benzamide
Synonyms: (±)-cis-N-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide; cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide; emonapride
Manufacturers' Codes: YM-09151-2
Trademarks: Emilace (Yamanouchi)
Molecular Formula: C21H26ClN3O2
Molecular Weight: 387.90
Percent Composition: C 65.02%, H 6.76%, Cl 9.14%, N 10.83%, O 8.25%
Literature References: Selective dopamine D2 receptor antagonist. Prepn: M. Takashima et al., JP Kokai 79 14965; eidem, US 4210660 (1979, 1980 both to Yamanouchi); S. Iwanami et al., J. Med. Chem. 24, 1224 (1981). Pharmacology: M. Yamamoto et al., Neuropharmacology 21, 945 (1982). Dopamine receptor binding study: C. W. Grewe et al., Eur. J. Pharmacol. 81, 149 (1982). Use as a label for D2 receptors: A. S. Unis et al., Life Sci. 47, PL151 (1990). HPLC determn in plasma: T. Nagasaki et al., J. Chromatogr. B 714, 293 (1998). Clinical evaluation in schizophrenia: K. Satoh et al., Int. Clin. Psychopharmacol. 11, 279 (1996).
Properties: Colorless crystals from isopropanol, mp 152-153° (Takashima, 1980). Also reported as mp 150° (Iwanami).
Melting point: mp 152-153° (Takashima, 1980); mp 150° (Iwanami)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Benzamides; Dopamine Receptor Antagonist.