Title: Sulodexide
CAS Registry Number: 57821-29-1
Synonyms: Glucuronylglucosamineglicane sulfate
Manufacturers' Codes: KRX-101
Trademarks: Provenal (Pulitzer); Ravenol (Caber); Vessel (Alfa)
Literature References: Orally active heparinoid prepared from porcine intestinal mucosa. Mixture of 80% electrophoretically fast moving heparin and 20% dermatan sulfate; average mol wt <8000. Preparative method: P. Bianchini,
DE 2426586;
idem,
US 3936351 (1975, 1976 both to Opocrin). Review of pharmacology: F. A. Ofosu,
Semin. Thromb. Hemostasis 24, 127-138 (1998); J. Harenberg,
Med. Res. Rev. 18, 1-20 (1998). Effect on albuminuria in diabetic patients: J. Skrha
et al., Diabetes Res. Clin. Pract. 38, 25 (1997). Clinical trial in venous leg ulcers: S. Coccheri
et al., Thromb. Haemostasis 87, 947 (2002); in deep venous thrombosis: B. M. Errichi
et al., Angiology 55, 243 (2004); in diabetic nephropathy: A. Achour
et al., J. Nephrol. 18, 568 (2005).
Therap-Cat: Antithrombotic; in treatment of chronic leg ulcers and diabetic nephropathy.
Keywords: Antithrombotic.