Home > Name List By other > (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5, 5a-t...

CAS No 751-97-3 , (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,
12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,
5a-tetrahydrotetracene-2-carboxamide

  • Name: (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,
    12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,
    5a-tetrahydrotetracene-2-carboxamide
  • Synonyms: (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,
    12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,
    5a-tetrahydrotetracene-2-carboxamide; Synterin; AC1NQZM8;Solvocillin; Rolitetracyclinum; Syntetrin; Rolitetraciclina; Kinteto; Synterin (TN); Pyrrolidino-methyl-tetracycline;
  • CAS Registry Number:
  • Flash Point: 452.363°C
  • Boiling Point: 824.37°C at 760 mmHg
  • Density: 1.542g/cm3
  • Refractive index: 1.713
  • Safety Statements: Poison by intravenous route. Experimental teratogenic effects. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xn
  • Flash Point: 452.363°C
  • EINECS: 212-031-9
  • Molecular Weight: 527.56622
  • InchiKey: IKQRPFTXKQQLJF-IAHYZSEUSA-N
  • InChI: InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-
    20(29(2)3)22(33)19(24(35)27(15,
    38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31-32,35,37-38H,
    4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
  • Risk Statements: 22-36/37/38
  • Molecular Formula: C27H33N3O8
  • Molecular Structure:CAS No:751-97-3 (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,<br />12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,<br />5a-tetrahydrotetracene-2-carboxamide

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References of (4S,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,
12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,
5a-tetrahydrotetracene-2-carboxamide
Title: Rolitetracycline
CAS Registry Number: 751-97-3
CAS Name: [4S-(4a,4aa,5aa,6b,12aa)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide
Synonyms: N-(pyrrolidinomethyl)tetracycline; N-(1-pyrrolidinylmethyl)tetracycline
Trademarks: Reverin (HMR); Syntetrin (BMS); Tetraverin (Polfa); Transcycline (HMR)
Molecular Formula: C27H33N3O8
Molecular Weight: 527.57
Percent Composition: C 61.47%, H 6.30%, N 7.96%, O 24.26%
Literature References: Semi-synthetic antibiotic prepd from tetracycline: Siedel et al., Muench. Med. Wochenschr. 100, 661 (1958); Lindner et al., ZA 5703169. Alternate procedure and structure: Gottstein et al., J. Am. Chem. Soc. 81, 1198 (1959); Cheney et al., US 3104240 (1963 to Bristol-Myers). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Fine, pale yellow needles, dec 162-165°. Amphoteric. More sol than tetracycline and tetracycline hydrochloride. Soly in water at 25°: 1.25 g/ml. Freely sol in alc. Sol in dil acids and alkalies.
 
Derivative Type: Nitrate sesquihydrate
CAS Registry Number: 26657-13-6
Trademarks: Bristacin (BMS); Pyrrocycline-N (Banyu)
Molecular Formula: C27H33N3O8.HNO3.1?H2O
Molecular Weight: 599.59
Percent Composition: C 54.09%, H 5.88%, N 9.34%, O 30.69%
Properties: LD50 i.v. in rats: 91 mg/kg (Goldenthal).
Toxicity data: LD50 i.v. in rats: 91 mg/kg (Goldenthal)
 
Derivative Type: Compd with chloramphenicol succinate
CAS Registry Number: 4154-10-3
Synonyms: Cafrolicycline; gradocycline; levocycline; senociclin
Trademarks: Clorociclin (Panthox & Burck); Crovicina (Viti); Metilcaf (Ital Suisse); Proterciclina (Proter); Reicaf (San Carlo); Tecaf (Farmochim. Ital.); Tetrafenicol (Medici Domus)
Molecular Formula: C27H33N3O8.C15H16Cl2N2O8
Molecular Weight: 950.77
Percent Composition: C 53.06%, H 5.19%, N 7.37%, O 26.92%, Cl 7.46%
Literature References: Prepn: BE 636234; Scevola, US 3218335 (1963, 1965 both to Lab. Pro-Ter).
Properties: Bright yellow powder, dec 140-144°. Bitter taste. Very sol in water. Practically insol in ether, ligroin, hexane.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Tetracyclines.