Home > Name List By other > (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11, 12a-pentahydroxy-3,12-dioxo-4a,5,5a, 6-tetrahydro-4H-tetracene-2-c...

CAS No 127-33-3 , (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,
12a-pentahydroxy-3,12-dioxo-4a,5,5a,
6-tetrahydro-4H-tetracene-2-carboxamide

  • Name: (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,
    12a-pentahydroxy-3,12-dioxo-4a,5,5a,
    6-tetrahydro-4H-tetracene-2-carboxamide
  • Synonyms: Declomycin; Demeclocycline HCL; CHEBI:4392;(4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,
    12a-pentahydroxy-3,12-dioxo-4a,5,5a,
    6-tetrahydro-4H-tetracene-2-carboxamide; Elkamicina; 127-33-3; DMCTC;
  • CAS Registry Number:
  • Flash Point: 367.8°C
  • Boiling Point: 684.5°Cat760mmHg
  • Density: 1.75g/cm3
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Human systemic effects by ingestion: diabetes insipidus, urine volume increase, other changes in urine composition, dermatitis, changes in the nails, allergic rhinitis, serum sickness, effects on cyclic nucleotides. Human reproductive effects by an unspecified route: postnatal measures or effects on newborn. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Flash Point: 367.8°C
  • EINECS: 204-834-8
  • Molecular Weight: 464.85304
  • InchiKey: GUXHBMASAHGULD-SEYHBJAFSA-N
  • InChI: InChI=1S/C21H21ClN2O8/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)
    15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31/h3-4,6-7,14-15,25-27,
    30,32H,5H2,1-2H3,(H2,23,31)/t6-,7-,14-,15-,21-/m0/s1
  • Molecular Formula: C21H21ClN2O8
  • Molecular Structure:CAS No:127-33-3 (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,<br />12a-pentahydroxy-3,12-dioxo-4a,5,5a,<br />6-tetrahydro-4H-tetracene-2-carboxamide

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References of (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,
12a-pentahydroxy-3,12-dioxo-4a,5,5a,
6-tetrahydro-4H-tetracene-2-carboxamide
Title: Demeclocycline
CAS Registry Number: 127-33-3
CAS Name: [4S-(4a,4aa,5aa,6b,12aa)]-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide
Synonyms: 7-chloro-6-demethyltetracycline; demethylchlortetracycline (obsolete)
Manufacturers' Codes: RP-10192
Trademarks: Bioterciclin; Declomycin (Wyeth); Deganol; Ledermycin (Wyeth); Periciclina
Molecular Formula: C21H21ClN2O8
Molecular Weight: 464.85
Percent Composition: C 54.26%, H 4.55%, Cl 7.63%, N 6.03%, O 27.53%
Literature References: Antibiotic related to tetracycline produced by Streptomyces aureofaciens. Prepn: McCormick et al., J. Am. Chem. Soc. 79, 4561 (1957); US 2878289 (1959 to Am. Cyanamid). Improved fermentation processes: Szumski, US 3012946; Goodman, Matrishin, US 3019172; Goodman, US 3050446 (1961, 1962, 1962 all to Am. Cyanamid); FR 1344645 (1963 to Merck & Co.); Neidleman, US 3154476 (1964 to Olin Mathieson). Abs config: Dobrynin et al., Tetrahedron Lett. 1962, 901. Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
 
Derivative Type: Sesquihydrate
Properties: mp 174-178° (dec). [a]D25 -258° (c = 0.5 in 0.1N H2SO4). Solubilities: Marsh, Weiss, J. Assoc. Off. Anal. Chem. 50, 457 (1967).
Melting point: mp 174-178° (dec)
Optical Rotation: [a]D25 -258° (c = 0.5 in 0.1N H2SO4)
 
Derivative Type: Hydrochloride
CAS Registry Number: 64-73-3
Trademarks: Clortetrin (Fargal); Demetraciclina (Bios); Detravis (Vis); Meciclin (Citobios); Mexocine (Specia)
Properties: LD50 orally in rats: 2372 mg/kg (Goldenthal).
Toxicity data: LD50 orally in rats: 2372 mg/kg (Goldenthal)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Tetracyclines.