Home > Name List By 1 > 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin- 1-yl]butan-1-one

CAS No 749-13-3 , 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-
1-yl]butan-1-one

  • Name: 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-
    1-yl]butan-1-one
  • Synonyms: 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-
    1-yl]butan-1-one; McN-JR-2498; Flumoperone; Trisedil; 749-13-3; Trisedyl; Psicoperidol; Psychoperidol;Triperidol; Psicoperidol-R;
  • CAS Registry Number:
  • Flash Point: 277.8°C
  • Boiling Point: 535.7°C at 760 mmHg
  • Density: 1.26g/cm3
  • Refractive index: 1.534
  • Safety Statements: Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F− and NOx. See also TRIFLUPERIDOL HYDROCHLORIDE.
  • Flash Point: 277.8°C
  • Molecular Weight: 409.417133
  • InchiKey: GPMXUUPHFNMNDH-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,
    11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2
  • Molecular Formula: C22H23F4NO2
  • Molecular Structure:CAS No:749-13-3 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-<br />1-yl]butan-1-one

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References of 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-
1-yl]butan-1-one
Title: Trifluperidol
CAS Registry Number: 749-13-3
CAS Name: 1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-1-butanone
Synonyms: 4￠-fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]butyrophenone; p-fluoro-4-[4￠-hydroxy-4￠-(3￠￠-trifluoromethyl)phenyl]piperidinobutyrophenone; 1-(3￠-p-fluorobenzoylpropyl)-4-hydroxy-4-(3￠￠-trifluoromethylphenyl)piperidine; w-[4-hydroxy-4-(m-trifluoromethylphenyl)piperidino]-p-fluorobutyrophenone; flumoperone
Molecular Formula: C22H23F4NO2
Molecular Weight: 409.42
Percent Composition: C 64.54%, H 5.66%, F 18.56%, N 3.42%, O 7.82%
Literature References: Prepn: P. A. J. Janssen, GB 895309; idem, US 3438991 (1962, 1969 both to Janssen). Pharmacology: idem, Arzneim.-Forsch. 11, 932 (1961).
 
Derivative Type: Hydrochloride
CAS Registry Number: 2062-77-3
Manufacturers' Codes: R-2498
Trademarks: Psicoperidol (Lusofarmaco); Psychoperidol (Ethnor); Triperidol (Janssen)
Molecular Formula: C22H23F4NO2.HCl
Molecular Weight: 445.88
Percent Composition: C 59.26%, H 5.43%, F 17.04%, N 3.14%, O 7.18%, Cl 7.95%
Properties: Crystals from acetone, mp 200.5-201.3°. Sol in water. LD50 in rats (mg/kg): 14 i.v.; 70 s.c. (Janssen, 1961).
Melting point: mp 200.5-201.3°
Toxicity data: LD50 in rats (mg/kg): 14 i.v.; 70 s.c. (Janssen, 1961)
 
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Butyrophenones.