Title: Croscarmellose Sodium
CAS Registry Number: 74811-65-7
Trademarks: Ac-Di-Sol (FMC)
Literature References: Internally cross-linked form of carboxymethylcellulose sodium (NaCMC),
q.v. Prepd by lowering pH of NaCMC in solution, then heating:
Technical Literature, FMC Corp. Use as tablet disintegrant: D. Gissinger, A. Stamm,
Pharm. Ind. 42, 189 (1980); M. E. Sangalli
et al., Boll. Chim. Farm. 128, 242 (1989). Evaluation of drug-excipient interaction: R. G. Hollenbeck
et al., J. Pharm. Sci. 72, 325 (1983). Water sorption and thermal behavior: D. Faroongsarng, G. E. Peck,
Drug Dev. Ind. Pharm. 20, 779 (1994). Mechanism of action study: R. Thibert, B. C. Hancock,
J. Pharm. Sci. 85, 1255 (1996).
Properties: Free flowing, odorless, white powder. Bulk density (g/cc) 0.48. pH 5.0-7.0. Hydrophillic. Insol in water.
Density: Bulk density (g/cc) 0.48
Use: Pharmaceutic aid (tablet disintegrant).
