Home > Name List By other > [4-[2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]ethyl]-2- ethoxycarbonyloxyphenyl] ethyl carbonate

CAS No 74639-40-0 , [4-[2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]ethyl]-2-
ethoxycarbonyloxyphenyl] ethyl carbonate

  • Name: [4-[2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]ethyl]-2-
    ethoxycarbonyloxyphenyl] ethyl carbonate
  • Synonyms: N-(N-Acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine; Docarpaminum [INN-Latin]; Docarpamina [INN-Spanish]; TA-8704; TA-870;[4-[2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]ethyl]-2-
    ethoxycarbonyloxyphenyl] ethyl carbonate;do Carpamine;
  • CAS Registry Number:
  • Flash Point: 395.9°C
  • Boiling Point: 731°C at 760 mmHg
  • Density: 1.222g/cm3
  • Refractive index: 1.529
  • Flash Point: 395.9°C
  • Molecular Weight: 470.5365
  • InchiKey: ZLVMAMIPILWYHQ-INIZCTEOSA-N
  • InChI: InChI=1S/C21H30N2O8S/c1-5-28-20(26)30-17-8-7-15(13-18(17)31-21(27)29-6-
    2)9-11-22-19(25)16(10-12-32-4)23-14(3)24/h7-8,13,16H,5-6,9-12H2,1-4H3,
    (H,22,25)(H,23,24)/t16-/m0/s1
  • Molecular Formula: C21H30N2O8S
  • Molecular Structure:CAS No:74639-40-0 [4-[2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]ethyl]-2-<br />ethoxycarbonyloxyphenyl] ethyl carbonate

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74639-40-0 DOCARPAMINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
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74639-40-0 Docarpamine

  • Docarpamine, Min 99%
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74639-40-0 Docarpamine

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  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
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74639-40-0 Docarpamine, 99.50%

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74639-40-0 DOCARPAMINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of [4-[2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]ethyl]-2-
ethoxycarbonyloxyphenyl] ethyl carbonate
Title: Docarpamine
CAS Registry Number: 74639-40-0
CAS Name: 4-[2-[[(2S)-2-(Acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
Synonyms: (-)-(S)-2-acetamido-N-(3,4-dihydroxyphenethyl)-4-(methylthio)butyramide bis(ethylcarbonate) (ester); N-(N-acetyl-L-methionyl)-O,O-bis(ethoxycarbonyl)dopamine; N-(N-acetyl-L-methionyl)-3,4-diethoxycarboxyphenethylamine
Manufacturers' Codes: TA-870
Trademarks: Tanadopa (Tanabe Seiyaku)
Molecular Formula: C21H30N2O8S
Molecular Weight: 470.54
Percent Composition: C 53.60%, H 6.43%, N 5.95%, O 27.20%, S 6.81%
Literature References: Dopamine prodrug. Prepn: T. Kiguchi et al., EP 7441; eidem, US 4228183 (both 1980 to Tanabe Seiyaku). Pharmacology: I. Yamaguchi et al., J. Cardiovasc. Pharmacol. 13, 879 (1989). Mechanism of action: S. Nishiyama et al., ibid. 14, 175 (1989). Pharmacokinetics: M. Yoshikawa et al., Drug Metab. Dispos. 16, 754 (1988). Metabolism in humans: eidem, ibid. 18, 212 (1990). HPLC determn in biological fluids: eidem, Biomed. Chromatogr. 4, 181 (1990). Review: S. Nishiyama et al., Cardiovasc. Drug Rev. 10, 101-116 (1992).
Properties: Crystals form ethyl acetate/n-hexane, mp 85-90°. [a]D20 -15.6° (c = 2 in methanol). Also reported as crystalline powder, mp 105-108° (Nishiyama, 1992). Slightly sol in water, readily sol in ethanol. LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992).
Melting point: mp 85-90°; mp 105-108° (Nishiyama, 1992)
Optical Rotation: [a]D20 -15.6° (c = 2 in methanol)
Toxicity data: LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.