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CAS No 74517-78-5 , 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide

  • Name: 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide
  • Synonyms: Ricainide; Indecainide [INN]; Decabid;Ricainid; Indecainida; Indecainida [Spanish]; Indecainidum [Latin]; INDECAINIDE; Indecainidum;9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide;
  • CAS Registry Number:
  • Flash Point: 261.8°C
  • Boiling Point: 509.3°C at 760 mmHg
  • Density: 1.109g/cm3
  • Refractive index: 1.585
  • Flash Point: 261.8°C
  • Molecular Weight: 308.41736
  • InchiKey: UCEWGESNIULAGX-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H24N2O/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-
    9-4-6-11-18(16)20/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23)
  • Molecular Formula: C20H24N2O
  • Molecular Structure:CAS No:74517-78-5 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide

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74517-78-5 INDECAINIDE

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74517-78-5 9H-Fluorene-9-carboxamide,9-[3-[(1-methylethyl)amino]propyl]-

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References of 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide
Title: Indecainide
CAS Registry Number: 74517-78-5
CAS Name: 9-[3-[(1-Methylethyl)amino]propyl]-9H-fluorene-9-carboxamide
Synonyms: 9-carbamoyl-9-(3-isopropylaminopropyl)fluorene; 9-[3-(isopropylamino)propyl]-9-(aminocarboyl)fluorene; ricainide
Molecular Formula: C20H24N2O
Molecular Weight: 308.42
Percent Composition: C 77.89%, H 7.84%, N 9.08%, O 5.19%
Literature References: Prepn: W. B. Lacefield, R. L. Simon, US 4197313 and US 4452745 (1980, 1984 both to Lilly). Pharmacokinetics in animals: T. L. Lindstrom, G. W. Whitaker, Drug Metab. Dispos. 12, 683 (1984). Metabolism: eidem, ibid. 691. LC determn in biological fluids: K. Z. Farid et al., J. Chromatogr. 337, 329 (1985). Toxicological studies: G. E. Sandusky, Jr., D. B. Meyers, Fundam. Appl. Toxicol. 5, 175 (1985). Clinical evaluation in cardiac arrhythmias: P. F. Nestico et al., Am. J. Cardiol. 59, 1332 (1987); P. J. Podrid et al., ibid. 61, 764 (1988).
Properties: Crystals from Skelly B, mp 94-95°.
Melting point: mp 94-95°
 
Derivative Type: Hydrochloride
CAS Registry Number: 73681-12-6
Manufacturers' Codes: LY-135837
Trademarks: Decabid (Lilly)
Molecular Formula: C20H24N2O.HCl
Molecular Weight: 344.88
Percent Composition: C 69.65%, H 7.31%, N 8.12%, O 4.64%, Cl 10.28%
Properties: Crystals from chloroform, mp 216.5-217°; also reported as crystals from fresh ethanol and diethyl ether, mp 203-204°. LD50 orally in male, female mice, rats: 100, 96, 103, 82 mg/kg (Sandusky, Meyers).
Melting point: mp 216.5-217°; mp 203-204°
Toxicity data: LD50 orally in male, female mice, rats: 100, 96, 103, 82 mg/kg (Sandusky, Meyers)
 
Therap-Cat: Antiarrhythmic (cardiac depressant).
Keywords: Antiarrhythmic.