Home > Name List By other > [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1, 4-benzodioxin-3-yl)methanone

CAS No 74191-85-8 , [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,
4-benzodioxin-3-yl)methanone

  • Name: [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,
    4-benzodioxin-3-yl)methanone
  • Synonyms: Doxazosinum; Doxazosinum [Latin]; Doxazosine; Normothen;[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,
    4-benzodioxin-3-yl)methanone; Doxazosina; Cardura-4; Doxazosine [French]; Cardura-1; Cardura-2;
  • CAS Registry Number:
  • Density: 1.371 g/cm3
  • Molecular Weight: 451.4751
  • InchiKey: RUZYUOTYCVRMRZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)
    28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,
    7-10,13H2,1-2H3,(H2,24,25,26)
  • Molecular Formula: C23H25N5O5
  • Molecular Structure:CAS No:74191-85-8 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,<br />4-benzodioxin-3-yl)methanone

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References of [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,
4-benzodioxin-3-yl)methanone
Title: Doxazosin
CAS Registry Number: 74191-85-8
CAS Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
Synonyms: 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline
Manufacturers' Codes: UK-33274
Molecular Formula: C23H25N5O5
Molecular Weight: 451.48
Percent Composition: C 61.19%, H 5.58%, N 15.51%, O 17.72%
Literature References: Selective a1-adrenergic blocker related to prazosin, q.v. Prepn: S. F. Campbell, DE 2847623; idem, US 4188390 (1979, 1980 both to Pfizer). Cardiovascular pharmacology: P. B. Timmermans et al., Arch. Int. Pharmacodyn. Ther. 245, 218 (1980). HPLC determn in plasma: M. G. Cowlishaw, J. R. Sharman, J. Chromatogr. 344, 403 (1985). Clinical pharmacokinetics: H. L. Elliott et al., Br. J. Clin. Pharmacol. 13, 699 (1982). Symposia on pharmacology and clinical efficacy in hypertension: Br. J. Clin. Pharmacol. 21, Suppl. 1, 1S-92S (1986); Am. J. Cardiol. 59, 1G-104G (1987). Review of clinical trials in benign prostatic hypertrophy: C. G. Roehrborn, R. L. Siegel, Urology 48, 406-415 (1996).
 
Derivative Type: Hydrochloride
Molecular Formula: C23H25N5O5.HCl
Molecular Weight: 487.94
Percent Composition: C 56.61%, H 5.37%, N 14.35%, O 16.39%, Cl 7.27%
Properties: Crystals, mp 289-290°.
Melting point: mp 289-290°
 
Derivative Type: Methanesulfonate
CAS Registry Number: 77883-43-3
Synonyms: Doxazosin mesylate
Manufacturers' Codes: UK-33274-27
Trademarks: Alfadil (Pfizer); Alfamedin (Kade); Benur (Pfizer); Cardenalin (Pfizer); Cardular (Pfizer); Cardura (Pfizer); Carduran (Pfizer); Diblocin (AstraZeneca); Doxamax (Esparma); Zoxan (Pfizer)
Molecular Formula: C23H25N5O5.CH3SO3H
Molecular Weight: 547.58
Percent Composition: C 52.64%, H 5.34%, N 12.79%, O 23.37%, S 5.86%
 
Therap-Cat: Antihypertensive; in treatment of benign prostatic hypertrophy.
Keywords: a-Adrenergic Blocker; Antihypertensive; Quinazoline Derivatives; Antiprostatic Hypertrophy.