Home > Name List By 3 > 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4, 5-dihydro-1H-pyridazin-6-one

CAS No 74150-27-9 , 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,
5-dihydro-1H-pyridazin-6-one

  • Name: 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,
    5-dihydro-1H-pyridazin-6-one
  • Synonyms: l-Pimobendan; d-Pimobendan; dl-Pimobendan; Acardi;pimobendane; Pimobendanum; Racemic pinobendan;3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,
    5-dihydro-1H-pyridazin-6-one; Vetmedin; 74150-27-9;
  • CAS Registry Number:
  • Density: 1.36
  • Refractive index: 1.692
  • Molecular Weight: 334.37182
  • InchiKey: GLBJJMFZWDBELO-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19
    (20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
  • Molecular Formula: C19H18N4O2
  • Molecular Structure:CAS No:74150-27-9 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,<br />5-dihydro-1H-pyridazin-6-one

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References of 3-[2-(4-methoxyphenyl)-3H-benzimidazol-5-yl]-4-methyl-4,
5-dihydro-1H-pyridazin-6-one
Title: Pimobendan
CAS Registry Number: 74150-27-9
CAS Name: 4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone
Synonyms: UD-CG 115; UD-CG 115 BS; 2-(4-methoxyphenyl)-5(6)-(5-methyl-3-oxo-4,5-dihydro-2H-6-pyridazinyl)benzimidazole
Molecular Formula: C19H18N4O2
Molecular Weight: 334.37
Percent Composition: C 68.25%, H 5.43%, N 16.76%, O 9.57%
Literature References: Positive inotropic agent. Prepn: V. Austel et al., DE 2837161; eidem, US 4361563 (1980, 1982 both to Thomae). Cardiovascular effects: J. C. A. von Meel, Arzneim.-Forsch. 35, 284 (1985); P. D. Verdouw et al., Eur. J. Pharmacol. 126, 21 (1986). Comparison of enantiomer activity: K. Fujino et al., J. Pharmacol. Exp. Ther. 247, 519 (1988). Clinical trial in congestive heart failure: F. Hagemeijer, Am. Heart J. 122, 517 (1991); S. D. Katz et al., ibid. 123, 95 (1992).
 
Derivative Type: Hydrochloride
CAS Registry Number: 77469-98-8
Molecular Formula: C19H18N4O2.HCl
Molecular Weight: 370.83
Percent Composition: C 61.54%, H 5.16%, N 15.11%, O 8.63%, Cl 9.56%
Properties: Crystals from methanol and ethereal HCl, mp 311°(dec). LD50 orally in mice: ~600 mg/kg (Austel, 1982).
Melting point: mp 311°(dec)
Toxicity data: LD50 orally in mice: ~600 mg/kg (Austel, 1982)
 
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.