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CAS No 72332-33-3 , 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one

  • Name: 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one
  • Synonyms: 60443-17-6; Procaterolum [Latin];Procaterolo [DCIT]; OPC-2009; 72332-33-3; Meptin; STK632659; EINECS 276-590-0; Procaterolum [INN-Latin];8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one;
  • CAS Registry Number:
  • Density: 1.191 g/cm3
  • EINECS: 276-590-0
  • Molecular Weight: 290.35748
  • InchiKey: FKNXQNWAXFXVNW-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14
    (20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)
  • Molecular Formula: C16H22N2O3
  • Molecular Structure:CAS No:72332-33-3 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one

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72332-33-3 Procaterol

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72332-33-3 Procaterol

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72332-33-3 Procaterol

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72332-33-3 (R*,S*)-(-)-8-HYDROXY-5-(1-HYDROXY-2-((1-METHYLETHYL)AMINO)BUTYL)-2(1H)-QUINOLINONE

  • China SHANGHAI RICHEM INTERNATIONAL CO., LTD. [Manufacturer]
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    Shanghai (200135), P.R.China null,nullChina
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References of 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one
Title: Procaterol
CAS Registry Number: 72332-33-3
CAS Name: rel-8-Hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-2(1H)-quinolinone
Synonyms: (±)-erythro-8-hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]carbostyril
Molecular Formula: C16H22N2O3
Molecular Weight: 290.36
Percent Composition: C 66.18%, H 7.64%, N 9.65%, O 16.53%
Literature References: Sympathomimetic amine with selective b2-adrenergic agonist activity. Prepn: K. Nakagawa et al., BE 823841; eidem, US 4026897 (1975, 1977 both to Otsuka); S. Yoshizaki et al., J. Med. Chem. 19, 1138 (1976). Prepn of optical isomers: eidem, ibid. 20, 1103 (1977). Assessment of selective action: H. Himori, N. Taira, Br. J. Pharmacol. 61, 9 (1977). Metabolism: Y. Yasuda et al., Arzneim.-Forsch. 29, 261 (1979). Pharmacokinetics: M. Ishigami et al., ibid. 266. Series of reproduction studies: Iyakuhin Kenkyu 10, 68-111 (1979), C.A. 90, 197728f-30a (1979). Antigenicity test: N. Nakagiri, S. Tei, Oyo Yakuri 17, 363 (1979), C.A. 91, 186577a (1979).
 
Derivative Type: Hydrochloride hemihydrate
CAS Registry Number: 81262-93-3
Manufacturers' Codes: OPC-2009
Trademarks: Lontermin (Lek); Masacin (Otsuka); Meptin (Otsuka); Onsukil (Otsuka); Procadil (Recordati); Promaxol (Otsuka); Propulm (DMS)
Molecular Formula: C16H22N2O3.HCl.?H2O
Molecular Weight: 335.83
Percent Composition: C 57.22%, H 7.20%, N 8.34%, O 16.67%, Cl 10.56%
Properties: Off-white crystalline powder, mp 193-197° (dec). Sol in methanol; slightly sol in ethanol. Practically insol in acetone, ether, ethyl acetate, chloroform, benzene. Colors on exposure to light. LD50 of the hydrochloride in male rats (mg/kg): 2600 orally, 80 i.v. (Nakagawa).
Melting point: mp 193-197° (dec)
Toxicity data: LD50 of the hydrochloride in male rats (mg/kg): 2600 orally, 80 i.v. (Nakagawa)
 
Therap-Cat: Bronchodilator.
Keywords: ?Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives.