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CAS No 71486-22-1 , Vinorelbine

  • Name: Vinorelbine
  • CAS Registry Number:
  • Density: 1.36 g/cm3
  • Refractive index: 1.676
  • Molecular Weight: 778.93
  • InChI: InChI=1/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28?,37-,38+,39+,42+,43+,44-,45-/m0/s1
  • Molecular Formula: C45H54N4O8
  • Molecular Structure:CAS No:71486-22-1 Vinorelbine
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71486-22-1 vinorelbine

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71486-22-1 vinorelbine

  • China Watson International Ltd. []
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, ,China
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71486-22-1 vinorelbine

  • China Xilin Chemical Group Co., Ltd []
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, ,China
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71486-22-1 vinorelbine

  • China ORCHID CHEMICAL SUPPLIES LTD (OCS) [Importer/Exporter]
  • Tel: +86-571-85395792
  • Fax: +86-571-85420103
  • Address: 607, North Zhongshan Road, Hangzhou 310000 China ,ZhejiangChina
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71486-22-1 Vinorelbine

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  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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71486-22-1 vinorelbine

  • Hong kong ADVANCED TECH. & IND. CO., LTD. [Distributor/Wholesaler]
  • Tel: 86-23902293
  • Fax: 86-27898314
  • Address: UNIT B, 1/F, CHEONG SHING IND. BLDG., 17 WALNUT ST., TAI KOK TSUI, KLN, HONG KONG Hong Kong,nilHong kong
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71486-22-1 vinorelbine

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71486-22-1 Navelbine

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71486-22-1 VINORELBINE(RG)

  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 ,United States
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References of Vinorelbine
Title: Vinorelbine
CAS Registry Number: 71486-22-1
CAS Name: (2b,3b,4b,5a,12R,19a)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester
Synonyms: 3¢,4¢-didehydro-4¢-deoxy-C¢-norvincaleukoblastine; nor-5¢-anhydrovinblastine; NVB
Manufacturers' Codes: KW-2307
Molecular Formula: C45H54N4O8
Molecular Weight: 778.93
Percent Composition: C 69.39%, H 6.99%, N 7.19%, O 16.43%
Literature References: Semi-synthetic Vinca alkaloid; structurally related to vinblastine, q.v. Prepn: JP Kokai 80 31096; N. Langlois et al., US 4307100 (1980, 1981 both to Agence Nat. Valorisation Recherche); P. Mangeney et al., Tetrahedron 35, 2175 (1979). Pharmacology: G. Mathé, P. Reizenstein, Cancer Lett. 27, 285 (1985). HPLC determn in biological fluids: F. Jehl et al., J. Chromatogr. 525, 225 (1990). Veterinary trial in dogs with spontaneous neoplasia: V. J. Poirier et al., J. Vet. Intern. Med. 18, 536 (2004). Symposium: Semin. Oncol. 16, Suppl. 4, 1-45 (1989). Review of early clinical development: M. Marty et al., Nouv. Rev. Fr. Hematol. 31, 77-84 (1989); of clinical pharmacokinetics: D. Leveque, F. Jehl, Clin. Pharmacokinet. 31, 184-197 (1996); of use in advanced non-small cell lung cancer: M. P. Curran, G. L. Plosker, Drugs Aging 19, 695-721 (2002).
Properties: Residue. [a]D20 +52.4° (c = 0.3 in CHCl3). uv max (ethanol): 215, 268, 282, 293, 310 nm (e 3700, 11000, 9500, 7600, 4400). Partition coefficient (octanol/buffer pH 7.2): 16. LD50 in mice (mg/m2): 72 i.v.; 78 orally (Mathé, Reizenstein).
Optical Rotation: [a]D20 +52.4° (c = 0.3 in CHCl3)
Log P: Partition coefficient (octanol/buffer pH 7.2): 16
Absorption maximum: uv max (ethanol): 215, 268, 282, 293, 310 nm (e 3700, 11000, 9500, 7600, 4400)
Toxicity data: LD50 in mice (mg/m2): 72 i.v.; 78 orally (Mathé, Reizenstein)
 
Derivative Type: Ditartrate
CAS Registry Number: 125317-39-7
Trademarks: Eunades (Pfizer); Navelbine (Fabre)
Molecular Formula: C45H54N4O8.2C4H6O6
Molecular Weight: 1079.11
Percent Composition: C 58.99%, H 6.16%, N 5.19%, O 29.65%
Properties: Yellow-white amorphous powder. Sol in water and ethanol.
 
Therap-Cat: Antineoplastic.
Therap-Cat-Vet: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Vinca Alkaloids.