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CAS No 69655-05-6 , 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one

  • Name: 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • Synonyms: Didanosina; DDI; Videx EC; Didanosinum; ddIno;DIDEOXYINOSINE; Hypoxanthine ddN; Videx; 2',3'-Dideoxyinosine;9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one;
  • CAS Registry Number:
  • Melting Point: 175 ºC
  • Flash Point: 308.5 ºC
  • Boiling Point: 586.5 ºC at 760 mmHg
  • Density: 1.76 g/cm3
  • Refractive index: -28 ° (C=0.34, H2O)
  • Water Solubility: 1-5 G/100 ML AT 21 ºC
  • Safety Statements: S26;S27;S36/37/39;S45;
  • Hazard Symbols: C
  • Flash Point: 308.5 ºC
  • Molecular Weight: 236.22728
  • InchiKey: BXZVVICBKDXVGW-NKWVEPMBSA-N
  • InChI: InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/
    h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
  • Risk Statements: 34-36/37
  • Molecular Formula: C10H12N4O3
  • Molecular Structure:CAS No:69655-05-6 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
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69655-05-6 Dideoxyinosine

  • Dideoxyinosine CAS: 69655-05-6 MF: C10H12N4O3 MW: 236.23 Chemical Properties White Powder Usage Used as an antiviral
  • China Wuhan Changland Technology Co.Ltd [Manufacturer]
  • Tel: 86-27-87290719
  • Fax: 86-27-68786490
  • Address: Changland Technology Co.,LTD Wuhan,HubeiChina
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69655-05-6 Didanosine

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69655-05-6 Didanosine

  • China Shanghai Hanhong Chemical Co., Ltd. [, Manufacturer, Trading Company, Agent]
  • Tel: +86-(21)-64762736, 64531573
  • Fax: +86-(21)-54291107
  • Address: 206-209, NO.1 Building , NO.245,Jiachuan Road, Xuhui District, Shanghai, Xuhui District,ShanghaiChina
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69655-05-6 Didanosine

  • China SHANGHAI HANHONG CHEMICAL CO.,LTD. [Manufacturers]
  • Tel: 021-64545202
  • Fax: 021-54291107
  • Address: Room 207, Zenghe Building , No.245, Jiachuan Road, Xuhui District, Shanghai, China shanghai,shanghaiChina
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69655-05-6 Didanosine

  • China BINHAI HANHONG BIOCHEMICAL CO., LTD. [Manufacturers]
  • Tel: +86-21-54302127
  • Fax: +86-21-54291107
  • Address: Room 209,Zonghe Building ,Jiachuan Road 245, Xuhui District, Shanghai, China Shanghai,ShanghaiChina
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69655-05-6 Didanosine

  • China Trust&We Co., Ltd. [Manufacturer]
  • Tel: +86-21-61044582
  • Fax: +86-21-61044583
  • Address: 1-102,No.11,Dongjiaominxiang Alley,
    Dongcheng District,
    Beijing 100005,China ,China
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69655-05-6 A1324 2'',3''-DIDEOXY-D-INOSINE

  • United Kingdom Carbosynth Limited [Manufacturer]
  • Tel: +44 (0)1635 578444
  • Fax: +44 (0)1635 579444
  • Address: Carbosynth Limited
    8&9 Old Station Business Park
    Compton
    Berkshire
    RG20 6NE
    UK ,United Kingdom
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69655-05-6 Didanosine

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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69655-05-6 Dideoxyinosine

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69655-05-6 Didanosine

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References of 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Title: Didanosine
CAS Registry Number: 69655-05-6
CAS Name: 2¢,3¢-Dideoxyinosine
Synonyms: dideoxyinosine; ddI; ddIno
Manufacturers' Codes: BMY-40900; NSC-612049
Trademarks: Videx (BMS)
Molecular Formula: C10H12N4O3
Molecular Weight: 236.23
Percent Composition: C 50.84%, H 5.12%, N 23.72%, O 20.32%
Literature References: Hypoxanthine nucleoside with antiviral activity; metabolic product of dideoxyadenosine, q.v. Enzymatic prepn from dideoxyadenosine: W. Plunkett, S. S. Cohen, Cancer Res. 35, 1547 (1975). Synthesis: G. W. Koszalka, T. A. Krenitsky, EP 206497 (1986 to Wellcome Found.); R. R. Webb et al., Nucleosides Nucleotides 7, 147 (1988). In vitro inhibition of HIV-I: H. Mitsuya, S. Broder, Proc. Natl. Acad. Sci. USA 83, 1911 (1986); of HIV-II: D. D. Richman, Antimicrob. Agents Chemother. 31, 1879 (1987). Antiretroviral spectrum in vitro: J. E. Dahlberg et al., Proc. Natl. Acad. Sci. USA 84, 2469 (1987). Cellular pharmacology in cloned human T-cells: G. Ahluwalia et al., Biochem. Pharmacol. 36, 3797 (1987). HPLC determn in human plasma: G. Ray, E. Murrill, Anal. Lett. 20, 1815 (1987). Clinical evaluations in AIDS: J. S. Lambert et al., N. Engl. J. Med. 322, 1333 (1990); T. P. Cooley et al., ibid. 1340. Comprehensive description: M. N. Nassar et al., Anal. Profiles Drug Subs. Excip. 22, 185-227 (1993).
Properties: White solid, mp 160-163°. Soly at 23° (mg/ml): acetone <1; acetonitrile <1; t-butanol <1; chloroform <1; dimethylacetamide 45; DMSO 200; ethanol 1; ethyl acetate <1; hexane <1; methanol 6; methylene chloride <1; polyethylene glycol-300 1; 1-propanol <1; 2-propanol <1; propylene glycol 8. pKa 9.12 ±0.02. Partition coefficient (1-octanol/0.05M phosphate buffer pH 7) 0.068 ±0.005. [a]D25 -26.3° (c = 10 in water). uv max 248 nm (pH 2); 254 nm (pH 12).
Melting point: mp 160-163°
pKa: pKa 9.12 ±0.02
Optical Rotation: [a]D25 -26.3° (c = 10 in water)
Log P: Partition coefficient (1-octanol/0.05M phosphate buffer pH 7) 0.068 ±0.005
Absorption maximum: uv max 248 nm (pH 2); 254 nm (pH 12)
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones; Reverse Transcriptase Inhibitor.