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CAS No 69049-73-6 , 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid

  • Name: 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid
  • Synonyms: Nedocromilo [Spanish]; Nedocromilum [Latin]; Nedocromilum; Alocril;Tilade; 69049-73-6;9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid; Nedocromil [USAN:BAN:INN]; Nedocromilo;
  • CAS Registry Number:
  • Density: 1.472 g/cm3
  • Refractive index: 1.64
  • Molecular Weight: 371.34078
  • InchiKey: RQTOOFIXOKYGAN-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14
    (22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)
  • Molecular Formula: C19H17NO7
  • Molecular Structure:CAS No:69049-73-6 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid

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References of 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Title: Nedocromil
CAS Registry Number: 69049-73-6
CAS Name: 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Synonyms: 4,6-dioxo-1-ethyl-10-propyl-4H,6H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid
Manufacturers' Codes: FPL-59002
Molecular Formula: C19H17NO7
Molecular Weight: 371.34
Percent Composition: C 61.45%, H 4.61%, N 3.77%, O 30.16%
Literature References: Mast cell stabilizer; also modulates production of cytokines by stimulated epithelial cells. Prepn and pharmacology: H. Cairns, D. Cox, BE 866622; eidem, US 4474787 (1978, 1984 both to Fisons); H. Cairns et al., J. Med. Chem. 28, 1832 (1985). Series of articles on pharmacology, pharmacokinetics and clinical profile in allergic rhinitis: Allergy 51, Suppl. 28, 8-34 (1996). Comparative clinical trial with cromolyn sodium, q.v., in asthma: H. J. Schwartz et al., Chest 109, 945 (1996).
Properties: Yellow powder, mp 298-300° (dec).
Melting point: mp 298-300° (dec)
 
Derivative Type: Disodium salt
CAS Registry Number: 69049-74-7
Manufacturers' Codes: FPL-59002KP
Trademarks: Halamid (Viatris); Irtan (Aventis); Rapitil (Aventis); Tilade (Aventis); Tilarin (Aventis); Tilavist (Aventis)
Molecular Formula: C19H15NNa2O7
Molecular Weight: 415.30
Percent Composition: C 54.95%, H 3.64%, N 3.37%, Na 11.07%, O 26.97%
Properties: Pale yellow powder. Sol in water.
 
Therap-Cat: Antiallergic; antiasthmatic.
Keywords: Antiallergic; Antiasthmatic (Nonbronchodilator).