Home > Name List By 5 > 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1, 3-thiazol-4-yl]thiophene-2-carboxamide

CAS No 68377-92-4 , 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,
3-thiazol-4-yl]thiophene-2-carboxamide

  • Name: 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,
    3-thiazol-4-yl]thiophene-2-carboxamide
  • Synonyms: S 596; Arotinololum [Latin];Arotinolol [INN]; Arotinolol (INN); 68377-92-4;5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,
    3-thiazol-4-yl]thiophene-2-carboxamide; ( -)-Arotinolol; S-596;
  • CAS Registry Number:
  • Melting Point: 148-149ºC
  • Density: 1.35 g/cm3
  • Molecular Weight: 371.54114
  • InchiKey: BHIAIPWSVYSKJS-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H21N3O2S3/c1-15(2,
    3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,
    19H,6-7H2,1-3H3,(H2,16,20)
  • Molecular Formula: C15H21N3O2S3
  • Molecular Structure:CAS No:68377-92-4 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,<br />3-thiazol-4-yl]thiophene-2-carboxamide

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References of 5-[2-[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl-1,
3-thiazol-4-yl]thiophene-2-carboxamide
Title: Arotinolol
CAS Registry Number: 68377-92-4
CAS Name: 5-[2-[[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide
Synonyms: 2-(3￠-tert-butylamino-2￠-hydroxypropylthio)-4-(5￠-carbamoyl-2￠-thienyl)thiazole
Molecular Formula: C15H21N3O2S3
Molecular Weight: 371.54
Percent Composition: C 48.49%, H 5.70%, N 11.31%, O 8.61%, S 25.89%
Literature References: Propanolamine deriv with a- and b-adrenergic blocking activity. Prepn: T. Hibino et al., DE 2341753; eidem, US 3932400 (1974, 1976 both to Sumitomo); Y. Hara et al., J. Pharm. Sci. 67, 1334 (1978). Characterization of adrenoceptor blocking effects in vivo: A. Miyagishi et al., Arch. Int. Pharmacodyn. Ther. 271, 249 (1984). Possible antianginal effects: M. Sakanashi et al., Oyo Yakuri 28, 709 (1984); C.A. 102, 39669z (1985). Long-term antihypertensive effect in rats: K. Kishi et al., J. Pharmacobio-Dyn. 8, 50 (1985). Comparison with timolol, q.v., of effect on intraocular pressure and hemodynamics: M. Nakashima et al., Eur. J. Clin. Pharmacol. 28, 391 (1985).
Properties: Crystals from chloroform/petroleum ether, mp 148-149°.
Melting point: mp 148-149°
 
Derivative Type: Hydrochloride
CAS Registry Number: 68377-91-3
Manufacturers' Codes: S-596; ARL
Trademarks: Almarl (Sumitomo)
Molecular Formula: C15H21N3O2S3.HCl
Molecular Weight: 408.00
Percent Composition: C 44.16%, H 5.43%, N 10.30%, O 7.84%, S 23.58%, Cl 8.69%
Properties: Crystals from methanol/water, mp 234-235.5° (dec). LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara).
Melting point: mp 234-235.5° (dec)
Toxicity data: LD50 in mice (mg/kg): 86 i.v., >360 i.p., >5000 orally (Hara)
 
Therap-Cat: Antihypertensive; antianginal; antiarrhythmic.
Keywords: a-Adrenergic Blocker; ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.