68367-52-2,(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione suppliers
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CAS No 68367-52-2 , (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione

  • Name: (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
  • Synonyms: AC1L7LJN; CP-45634; Sorbinilum [Latin]; Sorbinilo [Spanish]; 68367-52-2; Sorbinilum; Sorbinil (USAN/INN);Sorbinilo;(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.52g/cm3
  • Refractive index: 1.629
  • Flash Point: °C
  • Molecular Weight: 236.199163
  • InchiKey: LXANPKRCLVQAOG-NSHDSACASA-N
  • InChI: InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/
    h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
  • Molecular Formula: C11H9FN2O3
  • Molecular Structure:CAS No:68367-52-2 (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
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68367-52-2 SORBINIL

  • United States 2A PharmaChem USA [Manufacturer]
  • Tel: 630-322-8887
  • Fax: 630-322-8885
  • Address: 2A PharmaChem USA
    5403 Patton Drive, Suite 208
    Lisle, Illinois 60532 null,nullUnited States
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68367-52-2 SORBINIL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
Title: Sorbinil
CAS Registry Number: 68367-52-2
CAS Name: (4¢S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4¢-imidazolidine]-2¢,5¢-dione
Synonyms: (+)-(4S)-6-fluorospiro[chroman-4,4¢-imidazolidine]-2¢,5¢-dione
Manufacturers' Codes: CP-45634
Molecular Formula: C11H9FN2O3
Molecular Weight: 236.20
Percent Composition: C 55.93%, H 3.84%, F 8.04%, N 11.86%, O 20.32%
Literature References: Spirohydantoin aldose reductase inhibitor. Prepn of racemate and resolution of isomers: R. Sarges, DE 2821966; idem, US 4130714 (both 1978 to Pfizer). Synthesis: R. Sarges et al., J. Org. Chem. 47, 4081 (1982); N. L. Dirlam et al., J. Org. Chem. 52, 3587 (1987). Absolute configuration: R. Sarges et al., J. Med. Chem. 28, 1716 (1985). Effect on polyol accumulation in diabetic rats: M. J. Peterson et al., Metabolism 28, Suppl. 1, 456 (1979). Pharmacokinetics in humans: G. Foulds et al., Clin. Pharmacol. Ther. 30, 693 (1981). HPLC determn in human lens and plasma: P. Lloyd, M. J. C. Crabbe, J. Chromatogr. 343, 402 (1985). Preliminary clinical trials in diabetic neuropathy: R. J. Young et al., Diabetes 32, 938 (1983); J. Jaspan et al., Lancet 2, 758 (1983). Symposium on pharmacology and clinical efficacy: Metabolism 35, Suppl 1, 1-121 (1986).
Properties: Crystals from ethanol, mp 241-243°. [a]D25 +54.0° (c = 1 in methanol).
Melting point: mp 241-243°
Optical Rotation: [a]D25 +54.0° (c = 1 in methanol)