Home > Name List By 5 > 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2, 4-dione

CAS No 63612-50-0 , 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,
4-dione

  • Name: 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,
    4-dione
  • Synonyms: Nilutamidum; Nilandrone; Nilutamida; Nilandron; Nilutamidum [Latin];5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,
    4-dione; Nilutamida [Spanish];Anandron; 63612-50-0;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 1490C
  • Density: 1.463 g/cm3
  • Water Solubility: Insoluble in water
  • Safety Statements: R60;R25
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 317.22071
  • InchiKey: XWXYUMMDTVBTOU-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-
    6)12(13,14)15/h3-5H,1-2H3,(H,16,20)
  • Risk Statements: S53;S36/37/39;S45
  • Molecular Formula: C12H10F3N3O4
  • Molecular Structure:CAS No:63612-50-0 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,<br />4-dione

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References of 5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,
4-dione
Title: Nilutamide
CAS Registry Number: 63612-50-0
CAS Name: 5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione
Synonyms: 1-(3￠-trifluoromethyl-4￠-nitrophenyl)-4,4-dimethylimidazoline-2,5-dione
Manufacturers' Codes: RU-23908
Trademarks: Anandron (Cassenne); Nilandron (Aventis)
Molecular Formula: C12H10F3N3O4
Molecular Weight: 317.22
Percent Composition: C 45.43%, H 3.18%, F 17.97%, N 13.25%, O 20.17%
Literature References: Nonsteroidal antiandrogen. Prepn: J. Perronnet et al., DE 2649925; eidem, US 4097578 (1977, 1978 both to Roussel-UCLAF). Pharmacology: J.-P. Raynaud et al., J. Steroid Biochem. 11, 93 (1979). Review of kinetics, metabolism and clinical studies: idem et al., Prog. Clin. Biol. Res. 185A, 99-120 (1985); of therapeutic efficacy in prostate cancer: M. G. Harris et al., Drugs Aging 3, 9-25 (1993).
Properties: Crystals from ethanol, mp 149°. Freely sol in ethyl acetate, acetone, chloroform, ethanol, dichloromethane, methanol. Soly in water at 25°: < 0.1%.
Melting point: mp 149°
Therap-Cat: Antineoplastic (hormonal).
Keywords: Antiandrogen; Antineoplastic (Hormonal); Antiandrogens.