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CAS No 68-41-7 , D-Cycloserine

  • Name: D-Cycloserine
  • Synonyms: Cycloserine; (R)-4-AMINO-3-ISOXAZOLIDONE ;D-4-Amino-3-isoxazolidinone; (R)-(+)-CYCLOSERINE ; (R)-4-AMINO-ISOXAZOLIDIN-3-ONE ; ORIENTOMYCIN ; D-CYCLOSERINE, STREPTOMYCES ORCHIDACEUS ; D-4-AMINO-3-ISOXAZOLIDINONE ; (R)-4-AMINO-3-ISOXAZOLIDINONE ;D-Cycloserine; R(+)-4-AMINO-3-ISOXAZOLIDINONE ; SEROMYCIN ;
  • CAS Registry Number:
  • Melting Point: 147 ºC
  • Boiling Point: 267
  • Density: 1.278 g/cm3
  • Alpha: 111 º (C=5, 2N NAOH)
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by intravenous and subcutaneous routes. Mildly toxic by ingestion. Human systemic effects by ingestion and possibly other routes: wakefulness, sleep, altered sleep time, hallucinations, distorted perceptions, tremors, convulsions, and coma. An antibiotic used in the treatment of human pulmonary tuberculosis. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xn
  • EINECS: 200-688-4
  • Molecular Weight: 102.09
  • InChI: InChI=1/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
  • Risk Statements: S24/25
  • Molecular Formula: C3H6N2O2
  • Molecular Structure:CAS No:68-41-7 D-Cycloserine
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68-41-7 D-Cycloserine

  • D-Cycloserine
  • France CHEMSTEP [Manufacturer]
  • Tel: +33 556 405 186
  • Fax: +33 524 842 817
  • Address: CHEMSTEP
    20 Avenue Victor Hugo
    33560 Carbon Blanc
    FRANCE ,France
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68-41-7 D-Cycloserine

  • D-Cycloserine
  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
  • Fax: +49 (22 08) 7 75 02 30 /
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  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany ,Germany
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68-41-7 D-Cycloserine

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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68-41-7 D-Cycloserine

  • D-Cycloserine
  • United States INDOFINE Chemical Co., Inc. [Manufacturer]
  • Tel: (908) 359-6778
  • Fax: (908) 359-1179
  • Address: 121 Stryker Lane
    Bldg 30, Suite 1
    Hillsborough, NJ 08844 ,United States
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68-41-7 D-cycloserine

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68-41-7 D-Cycloserine

  • D-Cycloserine
  • Switzerland CONNECT MARKETING GMBH [Manufacturer]
  • Tel: +41 81 740 58 50
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  • Address: CONNECT MARKETING GMBH
    BAHNWEG NORD 35
    CH-9475 SEVELEN/SG
    SWITZERLAND ,Switzerland
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68-41-7 D-(+)-Cycloserine

  • D-(+)-Cycloserine
  • Hong kong Frapp's Pharma (Hongkong) Co.,Ltd [Manufacturer]
  • Tel: +852 8130 0917
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  • Address: Room 801,Mongkok Harbour Centre,638 Shanghai Street,Mongkok,Kowloon,Hongkang518001 MongkokHONG KONG Mongkok,Hong kong
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68-41-7 Cycloserine

  • CycloserineCycloserine, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,China
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68-41-7 Cycloserine

  • Cycloserine, 98%
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
  • Fax: +86-21-64968086
  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,China
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68-41-7 D-Cycloserine, synthetic

  • D-Cycloserine, synthetic
  • United States Chem-Impex International, Inc. [Manufacturer]
  • Tel: 630 766 2112
  • Fax: 630 766 2218
  • Address: 935 Dillon Drive Wood Dale IL 60191 USA ,United States
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References of D-Cycloserine
Title: Cycloserine
CAS Registry Number: 68-41-7
CAS Name: D-4-Amino-3-isoxazolidinone
Synonyms: D-4-amino-3-isoxazolidone; orientomycin
Manufacturers' Codes: PA-94; 106-7
Trademarks: Closina; Farmiserina (Farmitalia); Micoserina; Oxamycin (Merck & Co.); Seromycin (Lilly)
Molecular Formula: C3H6N2O2
Molecular Weight: 102.09
Percent Composition: C 35.29%, H 5.92%, N 27.44%, O 31.34%
Literature References: Antibiotic substance produced by Streptomyces garyphalus sive orchidaceus: Kuehl, Jr., et al., J. Am. Chem. Soc. 77, 2344 (1955); Hidy et al., ibid. 2345; Shull, Sardinas, Antibiot. Chemother. 5, 398 (1955); Shull et al., US 2773878 (1956 to Pfizer); Harned, US 2789983 (1957 to Commercial Solvents); GB 768007 (1957 to Commercial Solvents), C.A. 51, 10847e (1957); US 3124590 (1964 to Commercial Solvents); Howe, US 2845433 (1958 to Merck & Co.). Synthesis: Stammer et al., J. Am. Chem. Soc. 77, 2346 (1955); Peck, US 2772280 (1956 to Merck & Co.); Plattner et al., Helv. Chim. Acta 40, 1531 (1957); Holly, Stammer, US 2840565 (1958 to Merck & Co.). Prepn of crystalline calcium and magnesium salts: Harris et al., US 2832788 (1958 to Merck & Co.). HPLC determn in plasma and urine: D. G. Musson et al., J. Chromatogr. 414, 121 (1987). Comprehensive description: J. W. Lamb, Anal. Profiles Drug Subs. 1, 53-64 (1972); H. A. El-Obeid, A. A. Al-Badr, ibid. 18, 567-597 (1989).
Properties: Crystals, decomp 155-156°. [a]D23 +116° (c = 1.17); [a]25546 +137° (c = 5 in 2N NaOH). uv max: 226 nm (E1%1cm 402). Sol in water, slightly sol in methanol, propylene glycol. Aq solns have a pH around 6. Forms salts with acids and bases. Neutral or acid solns are unstable. Aq solns buffered to pH 10 with sodium carbonate can be stored without loss for one week at refrigerator temps.
Optical Rotation: [a]D23 +116° (c = 1.17); [a]25546 +137° (c = 5 in 2N NaOH)
Absorption maximum: uv max: 226 nm (E1%1cm 402)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Antibiotics); Antibacterial (Tuberculostatic).