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CAS No 674289-55-5 , (+/-)-blebbistatin

  • Name: (+/-)-blebbistatin
  • CAS Registry Number:
  • Flash Point: 260.586°C
  • Boiling Point: 507.267°C at 760 mmHg
  • Density: 1.312g/cm3
  • Refractive index: 1.681
  • Safety Statements: 26-36/37
  • Hazard Symbols: Xn
  • Flash Point: 260.586°C
  • Molecular Weight: 292.33184
  • InChI: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C18H16N2O2
  • Molecular Structure:CAS No:674289-55-5 (+/-)-blebbistatin

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674289-55-5 (+/-)-Blebbistatin

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674289-55-5 (+/-)-BLEBBISTATIN ( 1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE )

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References of (+/-)-blebbistatin
Title: Blebbistatin
CAS Registry Number: 674289-55-5
CAS Name: 1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Synonyms: 1-phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
Molecular Formula: C18H16N2O2
Molecular Weight: 292.33
Percent Composition: C 73.95%, H 5.52%, N 9.58%, O 10.95%
Literature References: Small molecule inhibitor of the ATPase activity of myosin II; affects cell blebbing during cell division. Prepn and inhibition of non-muscle myosin II: A. F. Straight et al., Science 299, 1743 (2003). Prepn and crystal structure of (-)-form: C. Lucas-Lopez et al., Eur. J. Org. Chem. 2005, 1736. Crystal structure in complex with myosin II: J. S. Allingham et al., Nat. Struct. Mol. Biol. 12, 378 (2005). Kinetics of non-muscle myosin IIB inhibition: B. Ramamurthy et al., Biochemistry 43, 14832 (2004). Mechanism of myosin II inhibition: M. Kovács et al., J. Biol. Chem. 279, 35557 (2004). Photochemistry studies: J. Kolega, Biochem. Biophys. Res. Commun. 320, 1020 (2004); T. Sakamoto et al., Biochemistry 44, 584 (2005).
Properties: Bright yellow solid, mp 192-193°. Absorption max (phosphate-buffered saline): 265, 430 nm.
Melting point: mp 192-193°
Absorption maximum: Absorption max (phosphate-buffered saline): 265, 430 nm
 
Derivative Type: (S)-Form
Synonyms: (-)-Blebbistatin
Properties: Crystals from acetonitrile, [a]D26 -464° (c = 0.2 in dichloromethane).
Optical Rotation: [a]D26 -464° (c = 0.2 in dichloromethane)
 
Use: In studies of cytoskeletal dynamics and the biological roles of class-II myosins.