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CAS No 672-87-7 , (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid

  • Name: (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
  • Synonyms: METYROSINE;(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; (S)-alpha-Methyltyrosine; Demser; Methyltyrosine; alpha-Methyl-L-tyrosine; Alpha-Methyl-L-P-Tyrosine; L-alpha-Methyl-p-tyrosine;Metirosine;
  • CAS Registry Number:
  • Flash Point: 185.9°C
  • Boiling Point: 383.7°C at 760 mmHg
  • Density: 1.283g/cm3
  • Refractive index: 1.599
  • Safety Statements: S22;S24/25
  • Flash Point: 185.9°C
  • EINECS: 211-599-5
  • Molecular Weight: 195.21512
  • InchiKey: NHTGHBARYWONDQ-JTQLQIEISA-N
  • InChI: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,
    1H3,(H,13,14)/t10-/m0/s1
  • Molecular Formula: C10H13NO3
  • Molecular Structure:CAS No:672-87-7 (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid

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References of (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
Title: Metyrosine
CAS Registry Number: 672-87-7
CAS Name: a-Methyl-L-tyrosine
Synonyms: a-methyl-p-tyrosine; a-methyltyrosine; 4-hydroxy-a-methylphenylalanine; a-methyl-3-(p-hydroxyphenyl)alanine; metirosine; L-a-MT; a-MPT
Manufacturers' Codes: MK-781
Trademarks: Demser (Merck & Co.)
Molecular Formula: C10H13NO3
Molecular Weight: 195.22
Percent Composition: C 61.52%, H 6.71%, N 7.17%, O 24.59%
Literature References: An inhibitor of the first and rate-limiting reaction in catecholamine biosynthesis, the hydroxylation of tyrosine to dopa. Prepn: NL 6607757 (1966 to Merck & Co.), C.A. 67, 91108p (1967). Prepn of DL-form: Stein et al., J. Am. Chem. Soc. 77, 700 (1955); Potts, J. Chem. Soc. 1955, 1632; Pfister, Stein, US 2868818 (1959 to Merck & Co.); Saari, J. Org. Chem. 32, 4074 (1967). Metabolism and biochemical and pharmacologic effects in man: Engelman et al., J. Clin. Invest. 47, 568, 577 (1968). Review of pharmacology and clinical use: R. N. Brogden et al., Drugs 21, 81-89 (1981).
Properties: Crystals, mp 310-315°.
Melting point: mp 310-315°
 
Derivative Type: DL-Form
CAS Registry Number: 620-30-4
Properties: Crystals from water, dec 320° (Stein et al., loc. cit.), also reported as dec 330-332° (Potts, loc. cit.). Soly in water at room temp: 0.57 mg/ml.
 
Therap-Cat: Tyrosine hydroxylase inhibitor; as antihypertensive in pheochromocytoma.
Keywords: Antipheochromocytoma.