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CAS No 66778-36-7 , 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide

  • Name: 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide
  • Synonyms: no stereochem; Encainide [INN:BAN]; Encainidum [Latin]; Encainide [French];4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide; Encainidum; Encainida [Spanish];Enkaid; Encainida;
  • CAS Registry Number:
  • Molecular Weight: 352.46992
  • InchiKey: PJWPNDMDCLXCOM-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22
    (25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,
    1-2H3,(H,23,25)
  • Molecular Formula: C22H28N2O2
  • Molecular Structure:CAS No:66778-36-7 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide

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66778-36-7 ENCAINIDE

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66778-36-7 Benzamide,4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-

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References of 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide
Title: Encainide
CAS Registry Number: 66778-36-7
CAS Name: 4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide
Synonyms: (±)-2￠-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide; 4-methoxy-2￠-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
Molecular Formula: C22H28N2O2
Molecular Weight: 352.47
Percent Composition: C 74.97%, H 8.01%, N 7.95%, O 9.08%
Literature References: Anti-arrhythmic benzanilide derivative. Prepn: S. J. Dykstra, J. L. Minielli, DE 2210154 (1972 to Bristol-Myers), C.A. 78, 4138j (1973); eidem, US 3931195 (1976 to Mead Johnson); S. J. Dykstra et al., J. Med. Chem. 16, 1015 (1973). Anti-arrhythmic pharmacology in animals: J. E. Byrne et al., J. Pharmacol. Exp. Ther. 200, 147 (1977). Clinical pharmacology and efficacy in chronic ventricular arrhythmia: D. M. Roden et al., N. Engl. J. Med. 302, 877 (1980). Electrophysiology and effects on cardiac conduction: M. Sami et al., Am. J. Cardiol. 44, 526 (1979). Hemodynamic effects: M. Sami et al., ibid. 52, 507 (1983). Adverse effects: R. A. Winkle et al., Am. Heart J. 102, 857 (1981). Comparison with other Class I anti-arrhythmic agents: A. Pottage, Am. J. Cardiol. 52, 24C (1983). Series of articles on pharmacology, pharmacokinetics, metabolism, clinical safety and efficacy: ibid. 58(5), 1C-116C (1986). Review: L. B. Mitchell, R. A. Winkle in New Drugs Annual: Cardiovascular Drugs vol. 1, A. Scriabine, Ed. (Raven Press, New York, 1983) pp 93-107.
 
Derivative Type: Hydrochloride
CAS Registry Number: 66794-74-9
Manufacturers' Codes: MJ-9067
Trademarks: Enkaid (Mead Johnson)
Molecular Formula: C22H28N2O2.HCl
Molecular Weight: 388.93
Percent Composition: C 67.94%, H 7.52%, N 7.20%, O 8.23%, Cl 9.12%
Properties: Crystals, mp 131.5-132.5°. Freely sol in water; slightly sol in ethanol. Insol in heptane. LD50 in mice, dogs (mg/kg): 86, 43 orally; 16, 17 i.v. (Mitchell, Winkle).
Toxicity data: LD50 in mice, dogs (mg/kg): 86, 43 orally; 16, 17 i.v. (Mitchell, Winkle)
 
Therap-Cat: Antiarrhythmic (class IC).
Keywords: Antiarrhythmic.