Home > Name List By other > (2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carbo...

CAS No 66148-78-5 , (2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,
3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

  • Name: (2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,
    3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Synonyms: Temocillinum; BRL 17421; Temocillinum [INN-Latin]; Temocillina; Temocillina [INN-Spanish];(2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,
    3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;Temocilline; Temocilline [INN-French];
  • CAS Registry Number:
  • Density: 1.6 g/cm3
  • Refractive index: 1.675
  • EINECS: 266-184-1
  • Molecular Weight: 414.45332
  • InchiKey: BVCKFLJARNKCSS-DWPRYXJFSA-N
  • InChI: InChI=1S/C16H18N2O7S2/c1-15(2)9(12(22)23)18-13(24)16(25-3,
    14(18)27-15)17-10(19)8(11(20)21)7-4-5-26-6-7/h4-6,8-9,14H,1-3H3,(H,17,
    19)(H,20,21)(H,22,23)/t8?,9-,14+,16-/m0/s1
  • Molecular Formula: C16H18N2O7S2
  • Molecular Structure:CAS No:66148-78-5 (2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,<br />3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

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References of (2S,5R,6S)-6-[(2-carboxy-2-thiophen-3-ylacetyl)amino]-6-methoxy-3,
3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Title: Temocillin
CAS Registry Number: 66148-78-5
CAS Name: (2S,5R,6S)-6-[(Carboxy-3-thienylacetyl)amino]-6-methoxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Synonyms: (6S)-6-[2-carboxy-2-(3-thienyl)acetamido]-6-methoxypenicillanic acid
Molecular Formula: C16H18N2O7S2
Molecular Weight: 414.45
Percent Composition: C 46.37%, H 4.38%, N 6.76%, O 27.02%, S 15.47%
Literature References: Semi-synthetic injectable penicillin deriv with high activity vs a large number of gram-negative bacteria, but with little activity vs gram-positive organisms. Prepn: J. P. Clayton, P. H. Bentley, DE 2600866 (1976 to Beecham), C.A. 86, 55420t (1977); P. H. Bentley et al., J. Chem. Soc. Perkin Trans. 1 1979, 2455. In vitro antibacterial activity and b-lactamase susceptibility: I. Phillips et al., J. Antimicrob. Chemother. 10, 271 (1982). Comparison to other penicillins vs H. influenzae and intestinal gram-negative rods: H. Y. Chen, J. D. Williams, ibid. 279. Pharmacokinetics and tissue penetration in healthy volunteers: R. M. Brown et al., ibid. 295. In vivo and in vitro comparison to ampicillin: R. Yogev et al., Antimicrob. Agents Chemother. 23, 182 (1983). Series of articles on microbiology, pharmacology and clinical studies: Drugs 29, Suppl. 5, 1-243 (1985).
 
Derivative Type: Disodium salt
CAS Registry Number: 61545-06-0
Manufacturers' Codes: BRL-17421
Trademarks: Temopen (SKB)
Molecular Formula: C16H16N2Na2O7S2
Molecular Weight: 458.42
Percent Composition: C 41.92%, H 3.52%, N 6.11%, Na 10.03%, O 24.43%, S 13.99%
Properties: Amorphous solid.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins.