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CAS No 65085-01-0 , Cefmenoxime

  • Name: Cefmenoxime
  • Synonyms: Cefmenoxime;(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid;
  • CAS Registry Number:
  • Density: 1.96 g/cm3
  • EINECS: 278-299-4
  • Molecular Weight: 511.55
  • InChI: InChI=1/C16H17N9O5S3/c1-24-16(20-22-23-24)33-4-6-3-31-13-9(12(27)25(13)10(6)14(28)29)19-11(26)8(21-30-2)7-5-32-15(17)18-7/h5,9,13H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29)/b21-8-/t9-,13-/m1/s1
  • Molecular Formula: C16H17N9O5S3
  • Molecular Structure:CAS No:65085-01-0 Cefmenoxime

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65085-01-0 Cefmenoxime

  • China Chemrio International Limited [Manufacturer]
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65085-01-0 Cefmenoxime

  • Cefmenoxime, 99.0+%
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65085-01-0 Cefmenoxlne

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65085-01-0 Cefmenoxime

  • China Inter-Chemical Ltd. [Manufacturers]
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References of Cefmenoxime
Title: Cefmenoxime
CAS Registry Number: 65085-01-0
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: (6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 72-(Z)-(O-methyloxime)
Manufacturers' Codes: SCE-1365
Molecular Formula: C16H17N9O5S3
Molecular Weight: 511.56
Percent Composition: C 37.57%, H 3.35%, N 24.64%, O 15.64%, S 18.80%
Literature References: Third generation cephalosporin antibiotic; related structurally to cefotaxime and ceftizoxime, q.q.v. The name cefmenoxime applies to the isomer having a syn-methoxyimino group. Prepn (unspecified stereochemistry): M. Ochiai et al., DE 2556736; eidem, US 4098888 (1976, 1978 both to Takeda); syn-isomer: R. Heymes, A. Lutz, DE 2713272; eidem, US 4476122 (1983, 1984 both to Roussel-Uclaf). Series of articles on antibacterial activity, absorption, excretion, metabolism, mechanism of action, clinical studies: Chemotherapy (Tokyo) 29, Suppl. 1, 1-998 (1979). In vitro and in vivo study: K. Tsuchiya et al., Antimicrob. Agents Chemother. 19, 56 (1981). b-Lactamase stability: K. Okonogi et al., ibid. 20, 171 (1981). Clinical pharmacokinetics study: D. H?ffler, P. Koeppe, Arzneim.-Forsch. 33, 269 (1983). Symposium: Am. J. Med. 77(6A), 1-59 (1984).
 
Derivative Type: Hydrochloride (syn-isomer)
CAS Registry Number: 75738-58-8
Manufacturers' Codes: Abbott 50192
Trademarks: Bestcall (Takeda); Cefmax (TAP); Cemix (Takeda); Tacef (Grñenthal)
Molecular Formula: (C16H17N9O5S3)2.HCl
Molecular Weight: 1059.58
Percent Composition: C 36.27%, H 3.33%, N 23.79%, O 15.10%, S 18.16%, Cl 3.35%
 
Derivative Type: Sodium salt (syn-isomer)
CAS Registry Number: 65085-02-1
Molecular Formula: C16H16N9NaO5S3
Molecular Weight: 533.54
Percent Composition: C 36.02%, H 3.02%, N 23.63%, Na 4.31%, O 14.99%, S 18.03%
Properties: [a]D20 -13.5 ±1° (c = 1 in water).
Optical Rotation: [a]D20 -13.5 ±1° (c = 1 in water)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.