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CAS No 6506-37-2 , 4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine

  • Name: 4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine
  • Synonyms: Acterol forte;Nitrimidazine; Acterol; Esclama; Naxogin; Nimorazolo; Nimorazol; Nulogyl;4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine; Naxofem;
  • CAS Registry Number:
  • Flash Point: 221.7°C
  • Boiling Point: 443°C at 760 mmHg
  • Density: 1.42g/cm3
  • Refractive index: 1.636
  • Safety Statements: Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS of AROMATIC HYDROCARBONS.
  • Flash Point: 221.7°C
  • EINECS: 229-394-4
  • Molecular Weight: 226.23246
  • InchiKey: MDJFHRLTPRPZLY-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,
    1-6H2
  • Molecular Formula: C9H14N4O3
  • Molecular Structure:CAS No:6506-37-2 4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine

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References of 4-[2-(5-nitroimidazol-1-yl)ethyl]morpholine
Title: Nimorazole
CAS Registry Number: 6506-37-2
CAS Name: 4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine
Synonyms: N-2-morpholinoethyl-5-nitroimidazole; 1-(2-N-morpholinylethyl)-5-nitroimidazole; nitrimidazine
Manufacturers' Codes: K-1900
Trademarks: Esclama (Montedison); Naxofem (Farmitalia); Naxogin (Erba)
Molecular Formula: C9H14N4O3
Molecular Weight: 226.23
Percent Composition: C 47.78%, H 6.24%, N 24.77%, O 21.22%
Literature References: Prepn: BE 667262; Giraldi, Mariotti, US 3399193 (1965, 1968 both to Carlo Erba); NL 6609552; NL 6609553; Gal and Carlson et al., US 3458528 and US 3646027 (1967, 1967, 1969, 1972, all to Merck & Co.). Synthesis and biological activity studies: Giraldi et al., Arzneim.-Forsch. 20, 52 (1970). Pharmacology and toxicology: de Carneri et al., Progr. Antimicrob. Anticancer Chemother., Proc. 6th Int. Congr. Chemother. vol. I, Tokyo, 1969 (Univ. of Tokyo Press, 1970, Tokyo) pp 149-154. Clinical results: Emanueli, de Carneri, ibid. vol. II, pp 369-372; Evans, Catterall, Br. Med. J. IV, 146 (1971). Metabolic studies: Giraldi, Biochem. Pharmacol. 20, 339 (1971). Acute toxicity data: B. Cavalleri et al., J. Med. Chem. 21, 781 (1978).
Properties: Crystals from water, mp 110-111°. Slightly sol in water at room temp; sol in alcohols, acetone, chloroform. LD50 orally in mice: 1530 mg/kg (Cavalleri).
Melting point: mp 110-111°
Toxicity data: LD50 orally in mice: 1530 mg/kg (Cavalleri)
Therap-Cat: Antiprotozoal (Trichomonas).
Keywords: Antiprotozoal (Trichomonas).