CAS No 65052-63-3 , Cefetamet hydrochloride

Title: Cefetamet
CAS Registry Number: 65052-63-3
CAS Name: (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: (6R,7R)-7-[2-(2-aminothiazol-4-yl)-(Z)-2-(methoxyimino)acetamido]-3-methyl-3-cephem-4-carboxylic acid; (6R,7R)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 72-(Z)-(O-methyloxime); deacetoxycefotaxime
Manufacturers' Codes: LY-097964; Ro-15-8074
Molecular Formula: C14H15N5O5S2
Molecular Weight: 397.43
Percent Composition: C 42.31%, H 3.80%, N 17.62%, O 20.13%, S 16.14%
Literature References: Third generation cephalosporin antibiotic. Prepn: R. Heymes, A. Lutz, DE 2713272; eidem, US 4396618 (1977, 1983 both to Roussel-UCLAF); R. Bucourt et al., Tetrahedron 34, 2233 (1978). Prepn of the pivaloyloxymethyl ester: M. Ochiai et al., DE 2715385; eidem, US 4680390 (1977, 1987 both to Takeda). Antibacterial spectrum: M. G. Thomas, S. D. R. Lang, Antimicrob. Agents Chemother. 29, 945 (1986). HPLC determn in biological fluids: R. Wyss, F. Bucheli, J. Chromatogr. 430, 81 (1988). Pharmacokinetics: K. Stoeckel et al., Curr. Med. Res. Opin. 11, 432 (1989). Multicenter clinical trial: L. Bernstein-Hahn et al., ibid. 442.
 
Derivative Type: Pivaloyloxymethyl ester
CAS Registry Number: 65243-33-6
Synonyms: Cefetamet pivoxil
Manufacturers' Codes: Ro-15-8075
Trademarks: Cefyl (Takeda); Globocef (Roche)
Molecular Formula: C20H25N5O7S2
Molecular Weight: 511.57
Percent Composition: C 46.96%, H 4.93%, N 13.69%, O 21.89%, S 12.54%
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.