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CAS No 644-62-2 , 2-(2,6-dichloro-3-methylanilino)benzoic acid

  • Name: 2-(2,6-dichloro-3-methylanilino)benzoic acid
  • Synonyms: Meclomen;2-(2,6-dichloro-3-methylanilino)benzoic acid; Acido meclofenamico;meclofenamate; CI-583; Meclomen (free acid); Meclophenamic acid; meclofenamic acid; 644-62-2; Arquel;
  • CAS Registry Number:
  • Flash Point: 195.3°C
  • Boiling Point: 399.4°C at 760 mmHg
  • Safety Statements: Poison by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx.
  • Flash Point: 195.3°C
  • EINECS: 211-419-5
  • Molecular Weight: 296.14864
  • InchiKey: SBDNJUWAMKYJOX-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14
    (18)19/h2-7,17H,1H3,(H,18,19)
  • Molecular Formula: C14H11Cl2NO2
  • Molecular Structure:CAS No:644-62-2 2-(2,6-dichloro-3-methylanilino)benzoic acid

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644-62-2 Meclofenamic acid

  • Meclofenamic acid Synonyms:Meclofen;Meclofenamic acid; CAS:644-62-2 Appearance:White Crystalline powder MF:C14H11Cl2NO2 MW:296.15 EINECS:211-419-5 mp:257-259°C Introduction: It can make inhibition of cyclooxygenase,which can reduce the biosynthesis o...
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644-62-2 Meclofenamic Acid

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644-62-2 Meclofenamic acid

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644-62-2 MECLOFENAMIC ACID ( 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID )

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References of 2-(2,6-dichloro-3-methylanilino)benzoic acid
Title: Meclofenamic Acid
CAS Registry Number: 644-62-2
CAS Name: 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid
Synonyms: N-(2,6-dichloro-m-tolyl)anthranilic acid; meclophenamic acid
Manufacturers' Codes: CI-583; INF-4668
Trademarks: Arquel (Parke-Davis)
Molecular Formula: C14H11Cl2NO2
Molecular Weight: 296.15
Percent Composition: C 56.78%, H 3.74%, Cl 23.94%, N 4.73%, O 10.80%
Literature References: Prepn: Scherrer, Short, DE 1149015 C.A. 61, 1801d (1964) and US 3313848 (1963, 1967 to Parke, Davis); Juby et al., J. Med. Chem. 11, 111 (1968). Pharmacology and toxicology: Winder et al., J. Pharmacol. Exp. Ther. 148, 422 (1965); Winder, Ann. Phys. Med. 1966, 7; Kaump, ibid. 16. Series of articles on structure-activity relationships, mechanism of action, clinical studies: Arzneim.-Forsch. 33, 619-680 (1983). Effect on prostaglandin E receptor binding: M. C. P. Rees et al., Lancet 2, 541 (1988).
Properties: White crystals from acetone-water, mp 257-259°; also reported as mp 248-250°. Soly (mg/ml): water 0.03; 0.1N NaOH 28. pH of satd aq soln: ~6.9.
Melting point: mp 257-259°; mp 248-250°
 
Derivative Type: Sodium salt monohydrate
Trademarks: Lenidolor (Menarini); Meclodol (Parke-Davis); Meclomen (Parke-Davis); Movens (Inverni)
Molecular Formula: C14H10Cl2NNaO2.H2O
Molecular Weight: 336.15
Percent Composition: C 50.02%, H 3.60%, Cl 21.09%, N 4.17%, Na 6.84%, O 14.28%
Properties: mp 289-291°. Soly in water: 15 mg/ml (slightly turbid). pH 8.7.
Melting point: mp 289-291°
 
Therap-Cat: Anti-inflammatory; antipyretic.
Therap-Cat-Vet: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives; Antipyretic.