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CAS No 64-77-7 , 1-butyl-3-(4-methylphenyl)sulfonylurea Search by region : China

  • Name: 1-butyl-3-(4-methylphenyl)sulfonylurea
  • Synonyms: Diabetol; Diabetamid; Dolipol; Diaben; Artosin; Rastinon;Orinase; Orabet; Butamide;1-butyl-3-(4-methylphenyl)sulfonylurea;
  • CAS Registry Number:
  • Melting Point: 128-130°C
  • Boiling Point: white crystalline powder
  • Density: 1.184 g/cm3
  • Safety Statements: Moderately toxic by ingestion and several other routes. A human teratogen. Human reproductive effects by ingestion and possibly other routes: stillbirth, developmental abnormalities of the cardiovascular (circulatory) system and urogenital system, and unspecified neonatal effects. Human systemic effects by ingestion: nausea or vomiting, hypoglycemia. Other experimental teratogenic and reproductive effects. Mutation data reported. Implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • EINECS: 200-594-3
  • Molecular Weight: 270.34792
  • InchiKey: JLRGJRBPOGGCBT-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,
    17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
  • Risk Statements: 20/21/22-40-43
  • Molecular Formula: C12H18N2O3S
  • Molecular Structure:CAS No:64-77-7 1-butyl-3-(4-methylphenyl)sulfonylurea

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References of 1-butyl-3-(4-methylphenyl)sulfonylurea
Title: Tolbutamide
CAS Registry Number: 64-77-7
CAS Name: N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide
Synonyms: 1-butyl-3-(p-tolylsulfonyl)urea; tolylsulfonylbutylurea; 3-(p-tolyl-4-sulfonyl)-1-butylurea; N-n-butyl-N￠-tosylurea; N￠-4-methylbenzenesulfonyl-N￠￠-butylurea; N-(sulfonyl-p-methylbenzene)-N￠-n-butylurea
Manufacturers' Codes: D-860; U-2043
Trademarks: Artosin (Roche); Diaben (Chugai); Dolipol (Aventis); Mobenol (Church & Dwight); Orabet (Berlin-Chemie); Orinase (Pharmacia & Upjohn); Oterben (Chinoin); Pramidex (Hospira); Rastinon (Aventis)
Molecular Formula: C12H18N2O3S
Molecular Weight: 270.35
Percent Composition: C 53.31%, H 6.71%, N 10.36%, O 17.75%, S 11.86%
Literature References: Description: Ehrhart, Naturwissenschaften 43, 93 (1956). Prepn: GB 808071; Aumüller, Herr, DE 1066575 (both 1959 to Hoechst); Ruschig et al., US 2968158 (1961 to Upjohn). Comprehensive description: W. F. Beyer, E. H. Jensen, Anal. Profiles Drug Subs. 3, 513-543 (1974).
Properties: Crystals, mp 128.5-129.5°.
Melting point: mp 128.5-129.5°
 
Derivative Type: Sodium salt
CAS Registry Number: 473-41-6
Molecular Formula: C12H17N2NaO3S
Molecular Weight: 292.33
Percent Composition: C 49.30%, H 5.86%, N 9.58%, Na 7.86%, O 16.42%, S 10.97%
Properties: mp 130-133°. Tetrahydrate, mp 41-43°.
Melting point: mp 130-133°; mp 41-43°
 
Therap-Cat: Antidiabetic.
Therap-Cat-Vet: Hypoglycemic agent.
Keywords: Antidiabetic; Sulfonylurea Derivatives.