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CAS No 1156-19-0 , 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea

  • Name: 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
  • Synonyms: Diabewas; Tolazamida; Tolazamidum; Tolanase; NCI-C03327;Tolinase;1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea; Norglycin; Tolazolamide; 1156-19-0;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.29g/cm3
  • Refractive index: 1.596
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: °C
  • EINECS: 214-588-3
  • Molecular Weight: 311.39984
  • InchiKey: OUDSBRTVNLOZBN-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H21N3O3S/c1-12-6-8-13(9-7-12)21(19,
    20)16-14(18)15-17-10-4-2-3-5-11-17/h6-9H,2-5,10-11H2,1H3,(H2,15,16,18)
  • Risk Statements: 22
  • Molecular Formula: C14H21N3O3S
  • Molecular Structure:CAS No:1156-19-0 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea

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1156-19-0 TOLAZAMIDE

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1156-19-0 Benzenesulfonamide,N-[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methyl-

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References of 1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
Title: Tolazamide
CAS Registry Number: 1156-19-0
CAS Name: N-[[(Hexahydro-1H-azepin-1-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Synonyms: 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)urea; N-(p-toluenesulfonyl)-N￠-hexamethyleniminourea; tolazolamide
Manufacturers' Codes: U-17835
Trademarks: Tolanase (Pharmacia & Upjohn)
Molecular Formula: C14H21N3O3S
Molecular Weight: 311.40
Percent Composition: C 54.00%, H 6.80%, N 13.49%, O 15.41%, S 10.30%
Literature References: Prepn: J. B. Wright, GB 887886 (1962 to Upjohn); J. B. Wright, R. E. Willette, J. Med. Pharm. Chem. 5, 815 (1962). Pharmacology: W. E. Dulin et al., Proc. Soc. Exp. Biol. Med. 107, 245 (1961). Mode of action study: Marshall et al., Metab. Clin. Exp. 19, 1046 (1970). Clinical experience and review of early literature: Balodimos, Marble, Curr. Ther. Res. 13, 6-12 (1971). Clinical bioavailability and pharmacokinetics: P. G. Welling et al., J. Pharm. Sci. 71, 1259 (1982). Structural studies: C. H. Koo et al., Arch. Pharmacal Res. 11, 74 (1988). HPLC determn in serum: B. J. Starkey et al., J. Liq. Chromatogr. 12, 1889 (1989). Comprehensive description: J. K. Lee et al., Anal. Profiles Drug Subs. Excip. 22, 489-516 (1993).
Properties: Crystals, mp 170-173°. Very slightly sol in water; slightly sol in alcohol; sol in acetone; freely sol in chloroform. pKa (25°): 3.6, pKa (37.5°): 5.68. LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin).
Melting point: mp 170-173°
pKa: pKa (25°): 3.6, pKa (37.5°): 5.68
Toxicity data: LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.