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CAS No 63516-07-4 , Flutropium bromide

  • Name: Flutropium bromide
  • Synonyms: Flutropium bromide;[8-(2-Fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide;
  • CAS Registry Number:
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx, Br−, and Cl−.
  • Molecular Weight: 478.39
  • InChI: InChI=1/C24H29FNO3.BrH/c1-26(15-14-25)20-12-13-21(26)17-22(16-20)29-23(27)24(28,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,20-22,28H,12-17H2,1H3;1H/q+1;/p-1/t20-,21-,22-,26?;/m1./s1
  • Molecular Formula: C24H29BrFNO3
  • Molecular Structure:CAS No:63516-07-4 Flutropium bromide

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63516-07-4 Flutropium Bromide

  • Flutropium Bromide
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References of Flutropium bromide
Title: Flutropium Bromide
CAS Registry Number: 63516-07-4
CAS Name: (endo,syn)-8-(2-Fluoroethyl)-3-[(hydroxydiphenylacetyl)oxy]-8-methyl-8-azoniabicyclo[3.2.1]octane bromide
Synonyms: (8r)-3a-benziloyloxy-8-(2-fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octane bromide; (8r)-8-(2-fluoroethyl)-3a-hydroxy-1aH,5aH-tropanium bromide benzilate; N-b-fluoroethylnortropine benzilate methobromide; benzilic acid N-b-fluoroethylnortropine ester methobromide
Manufacturers' Codes: Ba-598Br
Trademarks: Flubron (SS Pharm.)
Molecular Formula: C24H29BrFNO3
Molecular Weight: 478.39
Percent Composition: C 60.26%, H 6.11%, Br 16.70%, F 3.97%, N 2.93%, O 10.03%
Literature References: Anticholinergic agent. Prepn: R. Banholzer et al., DE 2540633; eidem, US 4042700 (both 1977 to Boehringer, Ing.). Synthesis: R. Banholzer et al., Arzneim.-Forsch. 36, 1161 (1986). Molecular and crystal structure: G. Kiel, ibid. 1166. Pharmacology in animals: S. Yanaura et al., Jpn. J. Pharmacol. 33, 971 (1983); R. Bauer, A. Fügner, Arzneim.-Forsch. 36, 1348 (1986). Pharmacodynamics: K. Yoshimura et al., Iyakuhin Kenkyu 18, 240 (1987), C.A. 107, 17197v (1987).
Properties: White crystals from acetonitrile, mp 192-193° (dec); from ethanol-acetone, mp 198-199° (dec). LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner).
Melting point: mp 192-193° (dec); mp 198-199° (dec)
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner)
Therap-Cat: Bronchodilator.
Keywords: Bronchodilator; Quaternary Ammonium Compounds; Antimuscarinic.