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CAS No 63329-53-3 , 2-(2-carboxyanilino)-4-chlorobenzoic acid

  • Name: 2-(2-carboxyanilino)-4-chlorobenzoic acid
  • Synonyms: 63329-53-3;2-(2-carboxyanilino)-4-chlorobenzoic acid; Lobenzaritum [INN-Latin]; 2-(2-carboxyanilino)-4-chlorobenzoic acid; 4-Chlor-2,2'-iminodibenzoesaiure;
  • CAS Registry Number:
  • Density: 1.515 g/cm3
  • Refractive index: 1.699
  • Molecular Weight: 291.6865
  • InchiKey: UGDPYGKWIHHBMB-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H10ClNO4/c15-8-5-6-10(14(19)20)12(7-8)16-11-4-2-1-3-9(11)13
    (17)18/h1-7,16H,(H,17,18)(H,19,20)
  • Molecular Formula: C14H10ClNO4
  • Molecular Structure:CAS No:63329-53-3 2-(2-carboxyanilino)-4-chlorobenzoic acid

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63329-53-3 Lobenzarit

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63329-53-3 Lobenzarit

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63329-53-3 Benzoic acid,2-[(2-carboxyphenyl)amino]-4-chloro-

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63329-53-3 LOBENZARIT

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References of 2-(2-carboxyanilino)-4-chlorobenzoic acid
Title: Lobenzarit
CAS Registry Number: 63329-53-3
CAS Name: 2-[(2-Carboxyphenyl)amino]-4-chlorobenzoic acid
Synonyms: N-(2-carboxyphenyl)-4-chloroanthranilic acid; 4-chloro-2,2￠-iminodibenzoic acid; CCA
Molecular Formula: C14H10ClNO4
Molecular Weight: 291.69
Percent Composition: C 57.65%, H 3.46%, Cl 12.15%, N 4.80%, O 21.94%
Literature References: Disease modifying antirheumatic drug (DMARD) with immunomodulating activity. Prepn: M. Tanemura et al., DE 2526092; eidem, US 4092426 (1976, 1978 both to Chugai). HPLC determn in plasma: F. J. Schwende, S. W. Turner, Pharm. Res. 8, 523 (1991). Immunosuppression of B cell activity: S. Hirohata et al., Arthritis Rheum. 35, 168 (1992). Clinical trial in rheumatoid arthritis: Y. Shiokawa et al., J. Rheumatol. 11, 615 (1984); in systemic lupus erythematosus: S. Hirohata et al., Clin. Exp. Rheumatol. 12, 261 (1994). Review of pharmacology: R. González, D. Remirez, Invest. Allergol. Clin. Immunol. 7, 77-82 (1997).
Properties: Crystals, mp >306°. LD50 in male, female rats (mg/kg): 2100, 2600 orally (Tanemura).
Melting point: mp >306°
Toxicity data: LD50 in male, female rats (mg/kg): 2100, 2600 orally (Tanemura)
 
Derivative Type: Disodium salt
CAS Registry Number: 64808-48-6
Trademarks: Carfenil (Chugai)
Molecular Formula: C14H8ClNNa2O4
Molecular Weight: 335.65
Percent Composition: C 50.10%, H 2.40%, Cl 10.56%, N 4.17%, Na 13.70%, O 19.07%
Properties: Solid, mp 388° (dec).
Melting point: mp 388° (dec)
 
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic.