Home > Name List By other > [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate Canada

CAS No 63-39-8 , [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen
phosphate Search by region : Canada

  • Name: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
    4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen
    phosphate
  • Synonyms: CHEBI:15713; 63-39-8; Uridine 5'-(tetrahydrogen triphosphate); Uteplex;uridine 5'-triphosphate; Uridine 5'-triphosphoric acid; 5'-UTP;[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
    4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen
    phosphate; UTP;
  • CAS Registry Number:
  • Flash Point: 113 °C
  • Density: 2.106 g/cm3
  • Safety Statements: 22-26-36
  • Hazard Symbols: Xn
  • Flash Point: 113 °C
  • EINECS: 200-558-7
  • Molecular Weight: 484.141086
  • InchiKey: PGAVKCOVUIYSFO-XVFCMESISA-N
  • InChI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28
    (19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,
    22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
  • Risk Statements: 20/21/22-68/20/21/22
  • Molecular Formula: C9H15N2O15P3
  • Molecular Structure:CAS No:63-39-8 [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,<br />4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen<br />phosphate

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63-39-8 Uridine5'-(tetrahydrogen triphosphate)

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References of [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen
phosphate
Title: Uridine 5￠-Triphosphate
CAS Registry Number: 63-39-8
CAS Name: Uridine 5￠-(tetrahydrogen triphosphate)
Synonyms: UTP
Molecular Formula: C9H15N2O15P3
Molecular Weight: 484.14
Percent Composition: C 22.33%, H 3.12%, N 5.79%, O 49.57%, P 19.19%
Literature References: Pyrimidine analog of ATP. Activates chloride channels in epithelial cells; increases ciliary beat frequency and induces degranulation of goblet cells in airway epithelia. Also effects inflammatory cell function and vascular reactivity. Isoln from rabbit muscle: Lipton et al., J. Am. Chem. Soc. 75, 5450 (1953). Synthesis: Kenner et al., J. Chem. Soc. 1954, 2288; Hall, Khorana, J. Am. Chem. Soc. 76, 5056 (1954). Review of bioactivity mediated by nucleotide receptors: S. E. O'Connor, Life Sci. 50, 1657-1664 (1992). Clinical effect on chloride secretion in cystic fibrosis: M. R. Knowles et al., Am. J. Respir. Crit. Care Med. 151, S65 (1995); on mucociliary clearance in combination with amiloride, q.v.: W. D. Bennett et al., ibid. 153, 1796 (1996).
 
Derivative Type: Trisodium salt dihydrate
Trademarks: Uteplex (Am. Home)
Molecular Formula: C9H12N2Na3O15P3.2H2O
Molecular Weight: 586.12
Percent Composition: C 18.44%, H 2.75%, N 4.78%, Na 11.77%, O 46.41%, P 15.85%
Properties: White powder, sol in water, very sparingly sol in alcohol. pKa1 6.6; pKa2 9.5. uv max (pH 7): 262 nm (aM 10,000); (pH 11): 261 nm (aM 8100).
pKa: pKa1 6.6; pKa2 9.5
Absorption maximum: uv max (pH 7): 262 nm (aM 10,000)
 
Therap-Cat: In treatment of cystic fibrosis.