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CAS No 62996-74-1 , Staurosporine

  • Name: Staurosporine
  • Synonyms: Alkaloid AM-2282 from Streptomyces;Staurosporine;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9a,10b,11b,13a)]-;Antibiotic 230;(+)-Staurosporine;Antibiotic AM 2282;Staurosporin;AM-2282;CGP39360;
  • CAS Registry Number:
  • Density: 1.56 g/cm3
  • Safety Statements: S53S36/S37
  • Hazard Symbols: Xn; T; Xi
  • Molecular Weight: 466.53
  • InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
  • Risk Statements: 40-45-36/37/38
  • Molecular Formula: C28H26N4O3
  • Molecular Structure:CAS No:62996-74-1 Staurosporine
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62996-74-1 Staurosporine

  • Staurosporine (AM-2282, SSP) can potently inhibit protein kinase C with IC50 of 2.7 nM. More information please visit the website: http://www.creative-enzymes.com/product/Staurosporine_2272.html
  • Min. Order: 10
  • United States Creative Enzymes [Manufacturer]
  • Tel: 1-516-6698109
  • Fax: 1-631-9388127
  • Address: 45-1 Ramsey Road, Shirley New York,New YorkUnited States
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62996-74-1 Staurosporine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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62996-74-1 STAUROSPORINE

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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62996-74-1 STAUROSPORINE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany ,Germany
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62996-74-1 STAUROSPORINE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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62996-74-1 STAUROSPORINE

  • United States Cayman Chemical Company [Manufacturer]
  • Tel: 734-975-3939; 734-975-3897 (Sales)/ 800-364-9897 (Customer Service)
  • Address: 1180 E.Ellsworth Rd.
    Ann Arbor, MI 48197
    800-364-9897 ,United States
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62996-74-1 STAUROSPORINE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland ,Switzerland
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62996-74-1 staurosporine

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62996-74-1 STAUROSPORINE, FREE BASE ANTIBIOTIC AM-2282; CGP-39360; ANTIBIOTIC 230

  • United States LC Laboratories [Manufacturer]
  • Tel: 781-937-0777
  • Fax: 781-938-5420
  • Address: LC Laboratories
    165 New Boston Street
    Woburn, MA 01801 USA ,United States
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62996-74-1 STAUROSPORINE FROM STREPTOMYCES SP.

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of Staurosporine
Title: Staurosporine
CAS Registry Number: 62996-74-1
CAS Name: (9S,10R,11R,13R)- 2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3¢,2¢,1¢-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Manufacturers' Codes: AM-2282; CGP-39360
Molecular Formula: C28H26N4O3
Molecular Weight: 466.53
Percent Composition: C 72.09%, H 5.62%, N 12.01%, O 10.29%
Literature References: Protein kinase C inhibitor; alkaloid isolated from Streptomyces staurosporeus. Isoln: S. Omura et al., J. Antibiot. 30, 275 (1977). Crystal and molecular structure: A. Furusaki et al., J. Chem. Soc. Chem. Commun. 1978, 800; eidem, Bull. Chem. Soc. Jpn. 55, 3681 (1982). Corrected stereochemistry: N. Funato et al., Tetrahedron Lett. 35, 1251 (1994). Total synthesis: J. T. Link et al., J. Am. Chem. Soc. 117, 552 (1995); idem et al., ibid. 118, 2825 (1996). Biosynthetic studies: D. Meksuriyen, G. A. Cordell, J. Nat. Prod. 51, 884, 893 (1988); S.-W. Yang et al., ibid. 62 1551 (1999). HPLC determn in blood and pharmacokinetics in rats: L. R. Gurley et al., J. Chromatogr. B 712, 211 (1998). Inhibition of protein kinase C: T. Tamaoki et al., Biochem. Biophys. Res. Commun. 135, 397 (1986); of other protein kinases: U. T. Rüegg, G. M. Burgess, Trends Pharmacol. Sci. 10, 218 (1989). Induction of apoptosis: E. Falcieri et al., Biochem. Biophys. Res. Commun. 193, 19 (1993); R. Bertrand et al., Exp. Cell Res. 211, 314 (1994); of tyrosine phosphorylation: D. Rasouly, P. Lazarovici, Eur. J. Pharmacol. 269, 255 (1994).
Properties: Pale yellow needles from chloroform-methanol as the methanol solvate, mp 270° (dec) (Omura). Also reported as yellow crystals from methanol, mp 288-291° (Meksuriyen, Cordell). [a]D25 +35.0° (c = 1 in methanol); [a]D22 +56.1° (c = 0.14 in methanol). uv max (methanol): 241.0, 266.0, 292.5, 321.5, 335.0, 355.0, 372.5 nm (log e 4.25, 4.26, 4.53, 3.88, 3.96, 3.81, 3.85). Sol in DMSO, DMF. Slightly sol in chloroform, methanol.
Melting point: mp 270° (dec); mp 288-291° (Meksuriyen, Cordell)
Optical Rotation: [a]D25 +35.0° (c = 1 in methanol); [a]D22 +56.1° (c = 0.14 in methanol)
Absorption maximum: uv max (methanol): 241.0, 266.0, 292.5, 321.5, 335.0, 355.0, 372.5 nm (log e 4.25, 4.26, 4.53, 3.88, 3.96, 3.81, 3.85)
 
Derivative Type: Hydrochloride
Molecular Formula: C28H26N4O3.HCl
Molecular Weight: 502.99
Percent Composition: C 66.86%, H 5.41%, N 11.14%, O 9.54%, Cl 7.05%
Properties: LD50 in mice (mg/kg): 6.6 i.p. (Omura).
Toxicity data: LD50 in mice (mg/kg): 6.6 i.p. (Omura)
 
Use: Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.