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CAS No 62893-19-0 , Cefoperazone

  • Name: Cefoperazone
  • Synonyms: Cefoperazone;[6R-[6alpha,7beta(R*)]]-7-[[[[(4-Ethyl-2,3-dioxo-1- piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; CPZ; Cefoperazone,sodium salt;Cefobid;
  • CAS Registry Number:
  • Melting Point: 169-171 C
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.77 g/cm3
  • Refractive index: 1.819
  • Safety Statements: S26;S36
  • Hazard Symbols: Xn
  • Flash Point: °C
  • EINECS: 263-749-4
  • Molecular Weight: 645.68
  • InChI: InChI=1/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15?,16-,22-/m1/s1
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C25H27N9O8S2
  • Molecular Structure:CAS No:62893-19-0 Cefoperazone

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References of Cefoperazone
Title: Cefoperazone
CAS Registry Number: 62893-19-0
CAS Name: (6R,7R)-7-[[(2R)-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 7-[D-(-)-a-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl)acetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic acid
Molecular Formula: C25H27N9O8S2
Molecular Weight: 645.67
Percent Composition: C 46.50%, H 4.21%, N 19.52%, O 19.82%, S 9.93%
Literature References: Broad spectrum third generation cephalosporin antibiotic. Prepn: I. Saikawa et al., BE 837682; eidem, US 4410522 (1976, 1983 both to Toyama); eidem, Yakugaku Zasshi 99, 929 (1979). Stability in aq soln: eidem, ibid. 1207. In vitro activity: M. V. Borobio et al., Antimicrob. Agents Chemother. 17, 129 (1980). Kinetics in rats: J. Fabre et al., Schweiz. Med. Wochenschr. 110, 264 (1980); in humans: A. F. Allaz, ibid. 109, 1999 (1979). Review of pharmacology and therapeutic efficacy: R. N. Brogden et al., Drugs 22, 423-460 (1981). Symposium on clinical studies: ibid. Suppl. 1, 1-124.
Properties: Crystals from acetonitrile/water, mp 169-171° (hydrated). Stable at pH 4.0-7.0; slightly unstable in acid; highly unstable in alkaline soln.
Melting point: mp 169-171° (hydrated)
 
Derivative Type: Sodium salt
CAS Registry Number: 62893-20-3
Manufacturers' Codes: CP-52640-2; T-1551
Trademarks: Bioperazone (Biopharma); Cefazone (Firma); Cefobid (Pfizer); Cefobine (Pfizer); Cefobis (Pfizer); Cefogram (Metapharma); Cefoneg (Tosi); Cefosint (Proter); Dardum (Lisapharma); Farecef (Lafare); Kefazon (Esseti); Novobiocyl (Francia); Pathozone (Pfizer); Peracef (Pfizer); Perocef (Pulitzer); Tomabef (Aandersen)
Molecular Formula: C25H26N9NaO8S2
Molecular Weight: 667.65
Percent Composition: C 44.97%, H 3.93%, N 18.88%, Na 3.44%, O 19.17%, S 9.61%
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.