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CAS No 62587-73-9 , Cefsulodin

  • Name: Cefsulodin
  • Synonyms: (6R,7R)-3-[(4-Carbamoylpyridin-1-ium-1-yl)methyl]-8-oxo-7-[[(2R)-2-phenyl-2-sulfoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Cefsulodin;
  • CAS Registry Number:
  • Safety Statements: 26-36
  • Hazard Symbols: Xn
  • Molecular Weight: 532.55
  • InChI: InChI=1/C22H20N4O8S2/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34)
  • Risk Statements: 20/21/22-36/37/38
  • Molecular Formula: C22H20N4O8S2
  • Molecular Structure:CAS No:62587-73-9 Cefsulodin
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62587-73-9 Cefsulodin

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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62587-73-9 Cefsulodin

  • Cefsulodin
  • United Kingdom Molekula Ltd [Manufacturer]
  • Tel: +44 1202 863000
  • Fax: +44 1202 863003
  • Address: Technology House Old Forge Road Ferndown Industrial Estate Wimborne Dorset Bh21 7RR null,nullUnited Kingdom
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62587-73-9 Cefsulodin

  • CefsulodinCefsulodin, 99%
  • China Beijing HuameiHuli Biochem Ltd [Manufacturers]
  • Tel: 010-86181995
  • Fax: 010-86860610
  • Address: Beijing TongZhou District Beijing,BeijingChina
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62587-73-9 Cefsulodin

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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62587-73-9 Cefsulodin

  • China Shanghai Richem International Co., Ltd. null
  • Tel: +86-(21)-31263688
  • Fax: +86-(21)-51862199
  • Address: Room 603, Golden Eagle Mansion A, No.1518 Minsheng Road, Pudong, Shanghai 200135, shanghai,shanghaiChina
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62587-73-9 CEFSULODIN

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62587-73-9 Cefsulodin

  • China Zibo Boke T&I Co., Ltd. null
  • Tel: +86-533-2362137
  • Fax: 86-533-2362170
  • Address: Zibo City ,Shandong,China null,ShandongChina
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62587-73-9 Cefsulodin

  • Hong kong Leawell International Limited [Importer/Exporter]
  • Tel: +852-(2576)-0298
  • Fax: +852-(2895)-4635
  • Address: 18/F Catic Plaza, 8 Causeway Road Causeway Bay, Guangzhou,GuangdongHong kong
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62587-73-9 (6R,7R)-3-[(4-CARBAMOYLPYRIDIN-1-IUM-1-YL)METHYL]-8-OXO-7-[[(2R)-2-PHENYL-2-SULFOACETYL]AMINO]-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE

  • China SHANGHAI RICHEM INTERNATIONAL CO., LTD. [Manufacturer]
  • Tel: +86-21-31263688
  • Fax: +86-21-51862199
  • Address: Room 603, Golden Eagle Mansion A,
    No.1518 Minsheng Road, Pudong,
    Shanghai (200135), P.R.China null,nullChina
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62587-73-9 Cefsulodin Sodium, 99.50%

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References of Cefsulodin
Title: Cefsulodin
CAS Registry Number: 62587-73-9
CAS Name: 4-(Aminocarbonyl)-1-[[(6R,7R)-2-carboxy-8-oxo-7-[[(2R)-phenylsulfoacetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium inner salt
Synonyms: 7-(a-sulphophenylacetamido)-3-(4¢-carbamoylpyridinium)methyl-3-cephem-4-carboxylic acid
Molecular Formula: C22H20N4O8S2
Molecular Weight: 532.55
Percent Composition: C 49.62%, H 3.79%, N 10.52%, O 24.03%, S 12.04%
Literature References: Third generation cephalosporin antibiotic. Prepn: S. Morimoto et al., DE 2234280; eidem, US 4065619 (1973, 1977 both to Takeda). Prepn and separation of isomers: H. Nomura et al., J. Med. Chem. 17, 1312 (1974). In vitro and in vivo antibacterial activity: K. Tsuchiya et al., Antimicrob. Agents Chemother. 13, 137 (1978). Absorption, distribution, excretion in mice, rats, dogs: eidem, J. Antibiot. 31, 593 (1978). Activity and susceptibility to b-lactamases: A. King et al., Antimicrob. Agents Chemother. 17, 165 (1980). In vitro comparison with other antibacterials: H. Grimm, Arzneim.-Forsch. 30, 1478 (1980). Clinical pharmacology: J. Fuellhaas et al., Curr. Chemother., Proc. 10th Int. Congr. Chemother. (Washington, D.C., 1978) 2, 848-851. Review of activity: H. C. Neu, B. E. Scully, Rev. Infect. Dis. 6, Suppl. 3, S667-S677 (1984). Review: A. Bryskier, Lyon Pharm. 34, 343-355 (1983); D. B. Wright, Drug Intell. Clin. Pharm. 20, 845-849 (1986).
 
Derivative Type: Sodium salt
CAS Registry Number: 52152-93-9
Synonyms: Sulcephalosporin
Manufacturers' Codes: Abbott 46811; CGP-7174/E; SCE-129
Trademarks: Cefomonil (TAP); Monaspor (Novartis); Pseudocef (Grñenthal); Pyocefal (Cassenne-Takeda); Takesulin (Takeda); Tilmapor (Novartis); Ulfaret (Takeda)
Molecular Formula: C22H19N4NaO8S2
Molecular Weight: 554.53
Percent Composition: C 47.65%, H 3.45%, N 10.10%, Na 4.15%, O 23.08%, S 11.56%
Properties: Colorless needles from ethanol/water, mp 175° (dec). LD50 in mice (mg/kg): >4000 i.p.; >15000 orally (Bryskier).
Melting point: mp 175° (dec)
Toxicity data: LD50 in mice (mg/kg): >4000 i.p.; >15000 orally (Bryskier)
 
Derivative Type: d-Form sodium salt
Properties: [a]D23 +16.5° (c = 1.08 in water). uv max (water): 263 nm (e 14600).
Optical Rotation: [a]D23 +16.5° (c = 1.08 in water)
Absorption maximum: uv max (water): 263 nm (e 14600)
 
Derivative Type: l-Form sodium salt
Properties: [a]D23 -16.8° (c = 1.01 in water).
Optical Rotation: [a]D23 -16.8° (c = 1.01 in water)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.