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CAS No 62571-86-2 , Captopril

  • Name: Captopril
  • Synonyms: (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline;Captopril; (S,S)-1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline; (s,s)-1-(d-3-mercapto-2-methyl-1-oxopropyl)-l-proline;(2s)-1-(3-mercapto-2-methylpropionyl)-l-proline;
  • CAS Registry Number:
  • Melting Point: 103-108 ºC
  • Density: 1.272 g/cm3
  • Refractive index: -127.5 ° (C=1.7, EtOH)
  • Alpha: -129.5 º (C=1, ETOH)
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 263-607-1
  • Molecular Weight: 217.28
  • InChI: InChI=1/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
  • Risk Statements: S26;S37/39
  • Molecular Formula: C9H15NO3S
  • Molecular Structure:CAS No:62571-86-2 Captopril

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62571-86-2 CAS:62571-86-2 Captopril

  • Basic Info Name:Captopril Apearance:White Powder CAS:62571-86-2 MF:C9H15NO3S MW:217.29 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated Em...
  • Min. Order: 1000
  • China Yuan Chen Co. Ltd [Manufacturer]
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62571-86-2 MF: C9H15NO3S Captopril

  • Basic Info Name:Captopril Apearance:White Powder CAS:62571-86-2 MF:C9H15NO3S MW:217.29 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated Em...
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  • China YuanChne Co. Ltd [Manufacturer]
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62571-86-2 MF: C9H15NO3S Captopril

  • Basic Info Name:Captopril Apearance:White Powder CAS:62571-86-2 MF:C9H15NO3S MW:217.29 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated Em...
  • Min. Order: 1000
  • China YuanChen Co. Ltd [Manufacturer]
  • Tel: 86-5075-6092
  • Address: 496 ZhongShan Road Wuhan,China
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62571-86-2 China Factory Price Captopril

  • Basic Info Name:Captopril Apearance:White Powder CAS:62571-86-2 MF:C9H15NO3S MW:217.29 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated Em...
  • Min. Order: 1000
  • China YuanChen Co. Ltd [Manufacturer]
  • Tel: 86-5075-6206
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  • Address: 496 ZhongShan Road. Wuhan,HubeiChina
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62571-86-2 CAPTORIL

  • Product Name: CAPTORIL Certification:ISO9001 CAS:62571-86-2 EINECS:263-607-1 Assay:99% M.F:C9H15N3S M.W:217.29 MP:103-108℃ BP:427.043℃ at 760 mmHg Density:0.862g/cm3 Appearance:White or white crystalline powder Application:Pharmaceutical Raw Materi...
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  • China Wuhan Hezhong Bio-Chemical Manufacture Co., Ltd [Manufacturer, Trading Company]
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  • Address: No. 496, Zhongshan Road, Wuchang District, Wuhan 430064, China. Wuhan,HebeiChina
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62571-86-2 Captopril

  • Captopril (Structural formula :) C9H15NO3S ( Molecular weight: )217.28 CAS NO.: 62571-86-2 Appearance: White to off-white crystalline power Use: The product is used as anti- hypertension medicament. Standard: USP29 Package: 25KG/Drum
  • China Wuhan Changland Technology Co.Ltd [Manufacturer]
  • Tel: 86-27-87290719
  • Fax: 86-27-68786490
  • Address: Changland Technology Co.,LTD Wuhan,HubeiChina
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62571-86-2 Captopril

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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62571-86-2 captopril

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
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  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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62571-86-2 captopril

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62571-86-2 Captopril

  • IUPAC NAME-(2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl] pyrrolidine-2-carboxylic acid MOLECULAR FORMULA-C9H15NO3S MOLAR MASS-217.29 Additionally, it has shown mood-elevating properties in some patients. This is consistent with the observation that anim...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Harsool Aurangabad,MaharashtraIndia

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References of Captopril
Title: Captopril
CAS Registry Number: 62571-86-2
CAS Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
Synonyms: (2S)-1-(3-mercapto-2-methylpropionyl)-L-proline; D-2-methyl-3-mercaptopropanoyl-L-proline
Manufacturers' Codes: SQ-14225
Trademarks: Acediur (Guidotti); Acepril (Duncan Flockhart); Alopresin (Alonga); Acepress (Guidotti); Capoten (BMS); Captolane (Th?aplix); Captoril (Sankyo); Cesplon (Esteve); Dilabar (Vita); Garranil (Aristegui); Hipertil (Normal); Lopirin (BMS); Lopril (BMS); Tensobon (Schwarz); Tensoprel (Rubio)
Molecular Formula: C9H15NO3S
Molecular Weight: 217.29
Percent Composition: C 49.75%, H 6.96%, N 6.45%, O 22.09%, S 14.76%
Literature References: First orally active angiotensin-converting enzyme (ACE) inhibitor. Prepn: M. A. Ondetti, D. W. Cushman, DE 2703828; eidem, US 4046889 and US 4105776 (1977, 1977, 1978 all to Squibb). Design and synthesis: M. A. Ondetti et al., Science 196, 441 (1977); D. W. Cushman et al., Biochemistry 16, 5484 (1977). Improved synthesis: D. H. Nam et al., J. Pharm. Sci. 73, 1843 (1984). Pharmacology: B. Rubin et al., Eur. J. Pharmacol. 51, 377 (1978); eidem, Prog. Cardiovasc. Dis. 21, 183 (1978). Clinical studies: D. B. Case et al., ibid. 195; H. R. Brunner et al., Ann. Intern. Med. 90, 19 (1979). Toxicology and metabolism: G. R. Keim in Captopril and Hypertension, D. B. Case, Ed. (Plenum, New York, 1980) p 137. GC/MS determn in biological fluids: T. Ito, Y. Matsuki, J. Chromatogr. 417, 79 (1987). Historical review and comprehensive bibliography: Z. P. Horovitz in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 148-175. Comprehensive description: H. Kadin, Anal. Profiles Drug Subs. 11, 79-137 (1982). Reviews: Am. Heart J. 104, pt. 2, 1125-1228 (1982); Br. J. Clin. Pharmacol. 14, Suppl. 2, 69S-252S (1982). Series of articles on pharmacology and therapeutic efficacy: Postgrad. Med. J. 62, Suppl. 1, 1-191 (1986).
Properties: Crystals from ethyl acetate/hexane, mp 103-104° (Ondetti, Cushman). Generally regarded as polymorphic: stable form, mp 106°; unstable form, mp 86° (Florey); also reported as mp 87-88°, resolidifies, second mp 104-105° (Cushman). [a]D22 -131.0° (c = 1.7 in ethanol). pK1 3.7, pK2 9.8. Freely sol in water, alc, chloroform, methylene chloride. LD50 in mice (mg/kg): 1040 i.v.; 6000 orally (Keim).
Melting point: mp 103-104° (Ondetti, Cushman); stable form, mp 106°; unstable form, mp 86°; mp 87-88°; resolidifies, second mp 104-105° (Cushman)
pKa: pK1 3.7, pK2 9.8
Optical Rotation: [a]D22 -131.0° (c = 1.7 in ethanol)
Toxicity data: LD50 in mice (mg/kg): 1040 i.v.; 6000 orally (Keim)
 
Derivative Type: Combination with hydrochlorothiazide
CAS Registry Number: 110075-07-5
Trademarks: Aceplus (BMS); Acezide (Duncan Flockhart); Capozide (BMS); Captea (Th?aplix); Ecazide (BMS)
 
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.