Home > Name List By other > (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4, 12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

CAS No 62-67-9 , (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,
12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

  • Name: (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,
    12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
  • Synonyms: Anarcon; Nalorphin; Nalorfina; Antorphin; Nalorphinium;(4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,
    12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol; Antorfin; Antorphine;Anthorphine; Allorphine;
  • CAS Registry Number:
  • Melting Point: 208 deg C
  • Flash Point: 252.3°C
  • Boiling Point: 493.6°C at 760 mmHg
  • Density: 1.38g/cm3
  • Refractive index: 1.699
  • Safety Statements: Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and other routes. Human systemic effects by parenteral and subcutaneous routes: central nervous system changes, excitement, tremors, hallucinations and distorted perceptions, and antianxiety effects. When heated to decomposition it emits very toxic fumes of NOx. See also ALLYL COMPOUNDS.
  • Flash Point: 252.3°C
  • EINECS: 200-546-1
  • Molecular Weight: 311.37494
  • InchiKey: UIQMVEYFGZJHCZ-SSTWWWIQSA-N
  • InChI: InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-
    11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,
    18-,19-/m0/s1
  • Molecular Formula: C19H21NO3
  • Molecular Structure:CAS No:62-67-9 (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,<br />12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

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62-67-9 nalorphine

  • IUPAC NAME-5α,6α)-17-allyl- 7,8-didehydro- 4,5-epoxymorphinan- 3,6-diol MOLECULAR FORMULA-C19H21NO3 MOLAR MASS-311.375 g/mol
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62-67-9 Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-(2-propen-1-yl)-, (5a,6a)-

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62-67-9 NALORPHINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of (4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,
12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Title: Nalorphine
CAS Registry Number: 62-67-9
CAS Name: (5a,6a)-7,8-Didehydro-4,5-epoxy-17-(2-propenyl)morphinan-3,6-diol
Synonyms: N-allylnormorphine; allorphine; antorphine; NANM
Molecular Formula: C19H21NO3
Molecular Weight: 311.37
Percent Composition: C 73.29%, H 6.80%, N 4.50%, O 15.42%
Literature References: Prepd from normorphine: McCawley et al., J. Am. Chem. Soc. 63, 314 (1941); amended procedure: Hart, McCawley, J. Pharmacol. 82, 339 (1944); Weijlard, Erickson, J. Am. Chem. Soc. 64, 869 (1942); US 2364833 (1944); Weijlard, US 2891954 (1959 to Merck & Co.). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: M. U. Zubair et al., Anal. Profiles Drug Subs. 18, 195-219 (1989).
Properties: Crystals from ether, mp 208-209° (not 92-93° as first given by McCawley). [a]D25 -155.3° (c = 3 in methanol). Sparingly sol in water, ether. Sol in alc, acetone, chloroform, dil alkalies. uv max (in acid): 285 nm; (in alkali): 298 nm.
Melting point: mp 208-209° (not 92-93° as first given by McCawley)
Optical Rotation: [a]D25 -155.3° (c = 3 in methanol)
Absorption maximum: uv max (in acid): 285 nm; (in alkali): 298 nm
 
Derivative Type: Hydrobromide
CAS Registry Number: 1041-90-3
Trademarks: Lethidrone (Burroughs Wellcome); Norfin (Lusofarmaco)
Molecular Formula: C19H21NO3.HBr
Molecular Weight: 392.29
Percent Composition: C 58.17%, H 5.65%, N 3.57%, O 12.24%, Br 20.37%
Properties: Crystals from alc, dec 258-259°. Sol in water.
 
Derivative Type: Hydrochloride
CAS Registry Number: 57-29-4
Trademarks: Nalline (Merck & Co.)
Molecular Formula: C19H21NO3.HCl
Molecular Weight: 347.84
Percent Composition: C 65.61%, H 6.37%, N 4.03%, O 13.80%, Cl 10.19%
Properties: Crystals from alc, mp 260-263°. Sol in water. Moderately sol in alc. uv max (water): 285 nm. IR and polarographic data: Seagers et al., J. Am. Pharm. Assoc. Sci. Ed. 41, 640 (1952). pH of 0.5% aq soln: 5.0. LD50 s.c. in rats: 1460 mg/kg (Goldenthal).
Melting point: mp 260-263°
Absorption maximum: uv max (water): 285 nm
Toxicity data: LD50 s.c. in rats: 1460 mg/kg (Goldenthal)
 
NOTE: This is a controlled substance: 21 CFR, 1308.13.
Therap-Cat: Narcotic antagonist.
Therap-Cat-Vet: Narcotic antagonist.
Keywords: Narcotic Antagonist.