Home > Name List By other > (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a, 13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7...

CAS No 16590-41-3 , (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,
13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one

  • Name: (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,
    13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
  • Synonyms: Naltrexona [INN-Spanish]; Naltrexonum [INN-Latin]; Vivitrol; Vivitrex;Celupan; N-Cyclopropylmethylnoroxymorphone; ReVia;(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,
    13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one; MorViva;
  • CAS Registry Number:
  • Melting Point: 168-170
  • Flash Point: 291.4°C
  • Boiling Point: 558.1°C at 760 mmHg
  • Density: 1.47g/cm3
  • Refractive index: 1.709
  • Safety Statements: Moderately toxic by subcutaneous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also (−)-MORPHINE and KETONES.
  • Flash Point: 291.4°C
  • EINECS: 240-649-9
  • Molecular Weight: 341.40092
  • InchiKey: DQCKKXVULJGBQN-XFWGSAIBSA-N
  • InChI: InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,
    16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,
    5-10H2/t15-,18+,19+,20-/m1/s1
  • Molecular Formula: C20H23NO4
  • Molecular Structure:CAS No:16590-41-3 (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,<br />13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one

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16590-41-3 Morphinan-6-one,17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5a)-

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References of (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,
13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one
Title: Naltrexone
CAS Registry Number: 16590-41-3
CAS Name: (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one
Synonyms: N-cyclopropylmethyl-14-hydroxydihydromorphinone
Manufacturers' Codes: UM-792
Molecular Formula: C20H23NO4
Molecular Weight: 341.40
Percent Composition: C 70.36%, H 6.79%, N 4.10%, O 18.75%
Literature References: Nonselective opioid receptor antagonist; congener of naloxone, q.v. Prepn: H. Blumberg et al., US 3332950 (1967 to Endo). Metabolism study: E. J. Cone, Tetrahedron Lett. 1973, 2607. Pharmacology and toxicity: R. P. Maickel et al., Ann. N.Y. Acad. Sci. 281, 321 (1976). Clinical pharmacology: E. R. Gritz et al., Clin. Pharmacol. Ther. 19, 773 (1976); K. Verebey et al., ibid. 20, 315 (1976). GC determn in urine: H. E. Dayton, C. E. Inturrisi, Drug Metab. Dispos. 4, 474 (1976). Review of pharmacokinetics and therapeutic use in opioid dependence: J. P. Gonzales, R. N. Brogden, Drugs 35, 192-213 (1988). Clinical trials in alcoholism: B. J. Berg et al., Drug Saf. 15, 274 (1996); R. S. Croop et al., Arch. Gen. Psychiatry 54, 1130 (1997).
Properties: Crystals from acetone, mp 168-170°. LD50 in mice (mg/kg): 586 s.c. (Maickel).
Melting point: mp 168-170°
Toxicity data: LD50 in mice (mg/kg): 586 s.c. (Maickel)
 
Derivative Type: Hydrochloride
CAS Registry Number: 16676-29-2
Manufacturers' Codes: EN-1639A
Trademarks: Antaxone (Zambon); Celupan (Lacer); Nalorex (DuPont Pharma); ReVia (DuPont Pharma)
Molecular Formula: C20H23NO4.HCl
Molecular Weight: 377.86
Percent Composition: C 63.57%, H 6.40%, N 3.71%, O 16.94%, Cl 9.38%
Properties: Crystals from methanol, mp 274-276°.
Melting point: mp 274-276°
 
Therap-Cat: Narcotic antagonist. In treatment of alcoholism.
Keywords: Narcotic Antagonist; Alcohol Dependence Treatment.