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CAS No 60200-06-8 , 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide

  • Name: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
  • Synonyms: Clorsulon [Spanish]; Clorsulonum [Latin];Curatrem; Ivomec-F; EINECS 262-100-2;4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide; MK-401; 60200-06-8; Clorsulone [French];
  • CAS Registry Number:
  • Transport: HAZARD
  • Melting Point: 200 - 207 C
  • Density: 1.8 g/cm3
  • Refractive index: 1.664
  • Hazard Symbols: UN NO.
  • EINECS: 262-100-2
  • Molecular Weight: 380.65582
  • InchiKey: QOVTVIYTBRHADL-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,
    15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
  • Molecular Formula: C8H8Cl3N3O4S2
  • Molecular Structure:CAS No:60200-06-8 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide

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References of 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
Title: Clorsulon
CAS Registry Number: 60200-06-8
CAS Name: 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide
Synonyms: 4-amino-6-(trichlorovinyl)-m-benzenedisulfonamide
Manufacturers' Codes: MK-401
Trademarks: Curatrem (Merial)
Molecular Formula: C8H8Cl3N3O4S2
Molecular Weight: 380.66
Percent Composition: C 25.24%, H 2.12%, Cl 27.94%, N 11.04%, O 16.81%, S 16.85%
Literature References: Benzenedisulfonamide deriv with fasciolicidal activity. Prepn: H. H. Mrozik, DE 2556122 (1976 to Merck & Co.), C.A. 85, 94100n (1976); H. Mrozik et al., J. Med. Chem. 20, 1225 (1977). GLC determn in biological fluids: W. J. A. Vanden Heuvel et al., J. Agric. Food Chem. 25, 389 (1977). Efficacy against liver fluke, Fasciola hepatica: D. A. Ostlind et al., Br. Vet. J. 133, 211 (1977); M. D. Schulman et al., J. Parasitol. 65, 555 (1979). In vitro inhibition of glycolysis: M. D. Schulman, D. Valentino, Exp. Parasitol. 49, 206 (1980). Mechanism of action: M. D. Schulman et al., Mol. Biochem. Parasitol. 5, 133 (1982). Pharmacokinetics: eidem, J. Parasitol. 68, 603 (1982).
Properties: Crystals from ether, mp 194-203°. Another crystal form from water, mp 203-205°. uv max (CH3OH): 325, 267, 227 nm (e 4530, 17395, 36310). LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind).
Melting point: mp 194-203°; mp 203-205°
Absorption maximum: uv max (CH3OH): 325, 267, 227 nm (e 4530, 17395, 36310)
Toxicity data: LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind)
Therap-Cat-Vet: Anthelmintic (Trematodes).