Title: Phloretin
CAS Registry Number: 60-82-2
CAS Name: 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
Synonyms: 2¢,4¢,6¢-trihydroxy-3-(
p-hydroxyphenyl)propiophenone; b-(
p-hydroxyphenyl)phloropropiophenone; b-(
p-hydroxyphenyl)-2,4,6-trihydroxypropiophenone
Molecular Formula: C15H14O5
Molecular Weight: 274.27
Percent Composition: C 65.69%, H 5.14%, O 29.17%
Literature References: The aglucon of phlorizin,
q.v. From root bark of apple trees: Rochleder,
J. Prakt. Chem. 98, 205 (1866). Structure: Seshadri,
Annu. Rev. Biochem. 20, 495 (1951). Synthesis: Fischer, Nouri,
Ber. 50, 611 (1917); Rosenmund, Rosenmund,
ibid. 61B, 2608 (1928); Shinoda
et al., J. Pharm. Soc. Jpn. 49, 797 (1929); Johnston,
US 2789995 (1957 to Union Carbide).
Properties: Needles from dil alcohol, dec 262°. Absorption spectrum: Lambrechts,
Arch. Int. Physiol. 44, Suppl., 1-39 (1937). Freely sol in alc, methanol, acetone; sol in alkalies in hot glacial acetic acid; very sparingly sol in benzene, chloroform. Practically insol in water, ether, the soly being increased by addition of alcohol.