Home > Name List By other > [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-diox...

CAS No 59985-21-6 , [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]
[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]
hydrogen phosphate

  • Name: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
    4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]
    [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
    4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]
    hydrogen phosphate
  • Synonyms: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
    4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]
    [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
    4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]
    hydrogen phosphate; Diquafosol [INN:BAN]; CHEMBL221326; CHEBI:27791;UppppU; P1,P4-Bis(5'-uridyl) tetraphosphate; AC1L3WMW; UNII-7828VC80FJ; Diquafosol [INN];
  • CAS Registry Number:
  • Density: 2.044g/cm3
  • Refractive index: 1.66
  • Molecular Weight: 790.307088
  • InchiKey: NMLMACJWHPHKGR-NCOIDOBVSA-N
  • InChI: InChI=1S/C18H26N4O23P4/c23-9-1-3-21(17(29)19-9)15-13(27)11(25)7(41-15)5-
    39-46(31,32)43-48(35,36)45-49(37,38)44-47(33,
    34)40-6-8-12(26)14(28)16(42-8)22-4-2-10(24)20-18(22)30/h1-4,7-8,11-16,
    25-28H,5-6H2,(H,31,32)(H,33,34)(H,35,36)(H,37,38)(H,19,23,29)(H,20,24,
    30)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
  • Molecular Formula: C18H26N4O23P4
  • Molecular Structure:CAS No:59985-21-6 [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,<br />4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]<br />[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,<br />4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]<br />hydrogen phosphate

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59985-21-6 Diquafosol

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References of [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]
[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,
4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]
hydrogen phosphate
Title: Diquafosol
CAS Registry Number: 59985-21-6
CAS Name: Uridine 5￠-(pentahydrogen tetraphosphate) P￠￠￠?5￠-ester with uridine
Synonyms: P1,P4-diuridine 5￠-tetraphosphate; UP4U
Molecular Formula: C18H26N4O23P4
Molecular Weight: 790.31
Percent Composition: C 27.36%, H 3.32%, N 7.09%, O 46.56%, P 15.68%
Literature References: Uridine nucleotide analog. P2Y2 purinoceptor agonist; stimulates mucin secretion from goblet cells. Prepn: M. J. Stutts, III et al., WO 9640059 (1996 to Univ. North Carolina at Chapel Hill); and receptor activity: W. Pendergast et al., Bioorg. Med. Chem. Lett. 11, 157 (2001). Ocular pharmacology: T. Fujihara et al., J. Ocul. Pharmacol. Ther. 18, 363 (2002). Review of development and therapeutic potential: J. Fischbarg, Curr. Opin. Invest. Drugs 4, 1377-1383 (2003); K. K. Nichols et al., Expert Opin. Invest. Drugs 13, 47-54 (2004). Clinical trial in dry eye disease: J. Tauber et al., Cornea 23, 784 (2004).
 
Derivative Type: Tetrasodium salt
CAS Registry Number: 211427-08-6
Manufacturers' Codes: INS-365
Molecular Formula: C18H22N4Na4O23P4
Molecular Weight: 878.23
Percent Composition: C 24.62%, H 2.52%, N 6.38%, Na 10.47%, O 41.90%, P 14.11%
 
Therap-Cat: In treatment of dry eye disease.
Keywords: Purinoceptor P2Y Agonist.