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CAS No 59937-28-9 , dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate

  • Name: dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate
  • Synonyms: Diisopropyl 1,3-dithiol-2-ylidenemalonate; Malotilatum [INN-Latin];malotilate; NKK 105; Malotilato [INN-Spanish]; 59937-28-9;dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate; NKK-105; Kantec;
  • CAS Registry Number:
  • Flash Point: 138.7°C
  • Boiling Point: 321.5°C at 760 mmHg
  • Density: 1.255g/cm3
  • Refractive index: 1.562
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx. See also ESTERS.
  • Flash Point: 138.7°C
  • EINECS: 261-987-3
  • Molecular Weight: 288.38304
  • InchiKey: YPIQVCUJEKAZCP-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H16O4S2/c1-7(2)15-10(13)9(11(14)16-8(3)4)12-17-5-6-18-12/h5-
    8H,1-4H3
  • Molecular Formula: C12H16O4S2
  • Molecular Structure:CAS No:59937-28-9 dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate

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59937-28-9 Malotilate

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59937-28-9 Malotilate, 99%

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59937-28-9 Malotilate

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59937-28-9 Malotilate

  • Malotilate CAS No: 59937-28-9 EINECS No: 261-987-3 Molecular formula: C12H16O4S2 Molecular weight: 288.383 Malotilate is used in the treatment of ALD because it inhibits CYP2E1 induced by alcohol. Email: sophia@international-biz.com MSN:hejing_jj@yah...
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References of dipropan-2-yl 2-(1,3-dithiol-2-ylidene)propanedioate
Title: Malotilate
CAS Registry Number: 59937-28-9
CAS Name: 1,3-Dithiol-2-ylidenepropanedioic acid bis(1-methylethyl) ester
Synonyms: diisopropyl 1,3-dithiol-2-ylidenemalonate
Manufacturers' Codes: NKK-105
Trademarks: Hepation (Nippon Chemiphar); Kantec (Daiichi)
Molecular Formula: C12H16O4S2
Molecular Weight: 288.38
Percent Composition: C 49.98%, H 5.59%, O 22.19%, S 22.24%
Literature References: Prepn from diisopropyl malonate: K. Taninaka et al., DE 2545569; eidem, US 4035387 (1976, 1977 both to Nihon Nohyaku); from the corresponding ketene mercaptide: H. Matsui et al., US 4327223 (1982 to Nihon Nohyaku). Effect on CCl4-induced liver injury in rats: Y. Imaizumi et al., Jpn. J. Pharmacol. 31, 15 (1981). Enhancement of rat liver protein synthesis: eidem, ibid. 32, 369 (1982). Pharmacokinetics and pharmacodynamics: M. Buhrer et al., Eur. J. Clin. Pharmacol. 30, 407 (1986). Clinical evaluation in liver cirrhosis: S. Takase et al., Gastroenterol. Jpn. 23, 639 (1988).
Properties: Pale yellow crystals, mp 60.5°. Sol in benzene, cyclohexane, n-hexane, ether.
Melting point: mp 60.5°
Therap-Cat: Hepatoprotectant.
Keywords: Hepatoprotectant.