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CAS No 599-79-1 , Salicylazosulfapyridine

  • Name: Salicylazosulfapyridine
  • Synonyms: salicylazosulfapyridine; Sulfasalazine; 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid; 5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid; Salazosulfapyridine;2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid; sulfasalazine;Salicylazosulfapyridine;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 240-245 ºC
  • Flash Point: 335.4ºC
  • Boiling Point: 630.9ºCat760mmHg
  • Density: 1.48g/cm3
  • Refractive index: 1.691
  • Water Solubility: <0.1 G/100 ML AT 25 ºC
  • Safety Statements: 22-29/56-45
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 335.4ºC
  • EINECS: 209-974-3
  • Molecular Weight: 398.39
  • InChI: InChI=1/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
  • Risk Statements: 42/43
  • Molecular Formula: C18H14N4O5S
  • Molecular Structure:CAS No:599-79-1 Salicylazosulfapyridine

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  • IUPAC NAME-2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid MOLECULAR FORMULA-C18H14N4O5S MOLAR MASS-398.394 g/mol
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References of Salicylazosulfapyridine
Title: Sulfasalazine
CAS Registry Number: 599-79-1
CAS Name: 2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid
Synonyms: 5-[p-(2-pyridylsulfamoyl)phenylazo]salicylic acid; salazosulfapyridine; 5-[4-(2-pyridylsulfamoyl)phenylazo]-2-hydroxybenzoic acid; 4-(pyridyl-2-amidosulfonyl)-3￠-carboxy-4￠-hydroxyazobenzene; salicylazosulfapyridine; sulphasalazine
Trademarks: Azulfidine (Pfizer); Colo-Pleon (Henning); Salazopyrin (Pfizer)
Molecular Formula: C18H14N4O5S
Molecular Weight: 398.39
Percent Composition: C 54.27%, H 3.54%, N 14.06%, O 20.08%, S 8.05%
Literature References: Conjugate of 5-aminosalicylic acid and sulfapyridine, q.q.v. Prepn and bactericidal effect: E. E. A. Askelof et al., US 2396145 (1946 to Pharmacia); Doraswamy, Guha, J. Indian Chem. Soc. 23, 278 (1946). Physicochemical properties: B. Nygard et al., Acta Pharm. Suec. 3, 313-342 (1966). Metabolism studies: H. Schroder, D. E. S. Campbell, Clin. Pharmacol. Ther. 13, 539 (1972); M. A. Peppercorn, P. Goldman, J. Pharmacol. Exp. Ther. 181, 555 (1972). HPLC determn in biological fluids: R. A. Hogezand et al., J. Chromatogr. 305, 470 (1984). Clinical trial in rheumatoid arthritis: D. E. Bax, R. S. Amos, Ann. Rheum. Dis. 44, 194 (1985). Review of clinical pharmacokinetics: U. Klotz, Clin. Pharmacokinet. 10, 285-302 (1985); of pharmacology and clinical use in inflammatory bowel disease: M. A. Peppercorn, Ann. Intern. Med. 3, 377 (1984); G. Watkinson, Drugs 32, Suppl. 1, 1-11 (1986). Comprehensive description: J. P. McDonnell, Anal. Profiles Drug Subs. 5, 515-532 (1976).
Properties: Minute, brownish-yellow crystals, dec 240-245°. uv max: 237 (E1%1cm ~658) and 359 nm. Slightly sol in alc. Practically insol in water, benzene, chloroform, ether.
Absorption maximum: uv max: 237 (E1%1cm ~658) and 359 nm
Therap-Cat: Anti-inflammatory (gastrointestinal).
Therap-Cat-Vet: Has been used in granulomatous colitis.
Keywords: Anti-inflammatory (Gastrointestinal); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives.